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Merck
모든 사진(1)

주요 문서

SAB2501424

Sigma-Aldrich

Anti-IGF1 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

동의어(들):

Anti-IGF1A, Anti-IGFI, Anti-OTTHUMP00000195084, Insulin-like growth factor 1, Insulin-like growth factor 1 (somatomedin C)

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

goat

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

종 반응성

human

기술

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... IGF1(3479)

일반 설명

Insulin-like growth factor 1 (IGF1) is a single polypeptide chain protein with three disulfide bridges. It is mainly produced by the liver and a wide range of extra-hepatic tissues. IGF1 is seen in normal and neoplastic breasts. The IGF1 gene is 84779 bp long and is made of 6 different exons. IGF-1 gene is located on human chromosome 12q23.2.

면역원

Peptide with sequence RSVRAQRHTD, from the internal region of the protein sequence according to NP_001104753.1; NP_001104754.1; NP_001104755.1; NP_000609.1

애플리케이션

Anti-IGF1 antibody produced in goat has been used in western blotting.

생화학적/생리학적 작용

Insulin-like growth factor 1 (IGF1) protein is essential for the development of children and adults. It plays a crucial role in general anabolic processes. IGF1 participates in differentiation and cell proliferation. It plays a key role in osteogenesis, muscle repair, and hypertrophy after trauma. IGF1 is also involved in the generation of axons in nerves and regeneration of a nerve after ischemic insult. It is known to participate in the clinical sequelae of Laron′s dwarfism. IGF1 is required for normal breast development.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

M Ouni et al.
The pharmacogenomics journal, 16(1), 102-106 (2015-04-15)
Short children using growth hormone (GH) to accelerate their growth respond to this treatment with a variable efficacy. The causes of this individual variability are multifactorial and could involve epigenetics. Quantifying the impact of epigenetic variation on response to treatments
IGF1 (Insulin-Like Growth Factor 1 (Somatomedin C))
Panayi ND and Burd R
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2013)
T L Wise
Genes, brain, and behavior, 16(2), 241-249 (2016-09-20)
Fragile X syndrome (FXS) is an inherited form of intellectual disability that is usually caused by expansion of a polymorphic CGG repeat in the 5' untranslated region of the X-linked FMR1 gene, which leads to hypermethylation and transcriptional silencing. Two
Marina Valente Barroso et al.
Bioorganic & medicinal chemistry, 25(20), 5557-5568 (2017-09-10)
Chronic obstructive pulmonary disease (COPD) is an incurable and progressive disease. Emphysema is the principal manifestation of COPD, and the main cause of this condition is cigarette smoke (CS). Natural products have shown antioxidant and anti-inflammatory properties that can prevent

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