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Merck
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Key Documents

SAB2702316

Sigma-Aldrich

Monoclonal Anti-CEP152 antibody produced in mouse

clone GT1315, affinity isolated antibody

동의어(들):

MCPH4, MCPH9, SCKL5

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

GT1315, monoclonal

형태

buffered aqueous solution

분자량

189kDa

종 반응성

human

농도

1mg/mL

기술

western blot: 1:500-1:3000

동형

IgG1

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... CEP152(22995)

일반 설명

CEP152 (centrosomal protein 152), a mammalian ortholog of Drosphila asterless is a component of mammalian centrosomes. It is located on human chromosome 15.

면역원

Recombinant protein encompassing a sequence within the N-terminus region of human CEP152.

애플리케이션

Suggested starting dilutions are as follows: WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

생화학적/생리학적 작용

This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq]
CEP152 (centrosomal protein 152) plays an important role in cell division and development. It is highly essential for the recruitment of centriole of Plk4 (polo-like kinase 4) and centriole duplication at the time of cell cycle.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

기타 정보

Purification: Affinity purified by Protein G

물리적 형태

Phosphate-buffered saline, no preservative added.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Primary autosomal recessive microcephaly: homozygosity mapping of MCPH4 to chromosome 15.
Jamieson CR, et al.
American Journal of Human Genetics, 65(5), 1465?1469-1465?1469 (1999)
Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4.
Guernsey DL, et al.
American Journal of Human Genetics, 87(1), 40-51 (2010)
Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.
Sonnen KF, et al.
Journal of Cell Science, 126(14), 3223-3233 (2013)

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