SAB2900181
Anti-FAP (AB1) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
동의어(들):
170-kDa melanoma membrane-bound gelatinase, FAP, FAP alpha, FAPA, Seprase, fibroblast activation protein, fibroblast activation protein alpha
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모든 사진(1)
About This Item
UNSPSC 코드:
12352203
NACRES:
NA.41
결합:
unconjugated
application:
IHC
클론:
polyclonal
종 반응성:
human
citations:
9
기술:
immunohistochemistry: 10-20 μg/mL
추천 제품
관련 카테고리
일반 설명
FAP gene is localized on human chromosome 2q24.2.
Fibroblast activation protein (FAP) is a type II transmembrane serine protease and a cell surface antigen. It is present as a homodimeric integral protein with dipeptidyl peptidase IV like fold. FAP has an α/β-hydrolase domain and an eight-bladed β-propeller domain. It is not expressed in normal tissues. The protein is only expressed by activated fibroblasts in response to pathologic situations.
면역원
Synthetic 18 amino acid peptide from extracellular domain of human FAP. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (94%); Bovine (89%); Marmoset (83%).
애플리케이션
Anti-FAP (AB1) antibody produced in rabbit has been used in immunohistochemistry.
생화학적/생리학적 작용
Fibroblast activation protein (FAP) is expressed in several pathogenic sites including cancer, fibrosis, arthritis, wounding, or inflammation. FAP has in vitro dipeptidyl peptidase activity and collagenolytic activity. It cleaves N-terminal dipeptides from polypeptides and can degrade gelatin and type I collagen.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Solution in phosphate-buffered saline containing less than 0.1% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Fibroblast Activation Protein, a Dual Specificity Serine Protease Expressed in Reactive Human Tumor Stromal Fibroblasts*
John E Park
The Journal of Biological Chemistry (1999)
Fibroblast activation protein-a: a key modulator of the microenvironment in multiple pathologies
Thomas Kelly-
International Review of Cell and Molecular Biology, 297 (2012)
Ellen Puré et al.
Oncogene, 37(32), 4343-4357 (2018-05-04)
Fibroblast activation protein (FAP) is a cell-surface serine protease that acts on various hormones and extracellular matrix components. FAP is highly upregulated in a wide variety of cancers, and is often used as a marker for pro-tumorigenic stroma. It has
Xuguang Yang et al.
Cancer research, 76(14), 4124-4135 (2016-05-25)
Cancer-associated fibroblasts (CAF) are components of the tumor microenvironment whose contributions to malignant progression are not fully understood. Here, we show that the fibroblast activation protein (FAP) triggers induction of a CAF subset with an inflammatory phenotype directed by STAT3
L Wagner et al.
Clinical and experimental immunology, 184(3), 265-283 (2015-12-17)
Dipeptidyl peptidase (DPP) 4 (CD26, DPP4) is a multi-functional protein involved in T cell activation by co-stimulation via its association with adenosine deaminase (ADA), caveolin-1, CARMA-1, CD45, mannose-6-phosphate/insulin growth factor-II receptor (M6P/IGFII-R) and C-X-C motif receptor 4 (CXC-R4). The proline-specific
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