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Merck
모든 사진(1)

Key Documents

SAB3500010

Sigma-Aldrich

Anti-FNIP2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution, ab2

동의어(들):

Anti-FNIPL, Anti-Folliculin interacting protein 2

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

종 반응성

rat, mouse, human

기술

indirect ELISA: suitable
western blot: suitable

NCBI 수납 번호

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... FNIP2(57600)

일반 설명

Folliculin interacting protein 2 (FNIP2) is a 125.6kDa protein expressed in the cytoplasm.

면역원

FNIP2 antibody was raised against an 18 amino acid peptide near the amino terminus of human FNIP2.

생화학적/생리학적 작용

Folliculin interacting protein 2 (FNIP2) induces apoptosis. It associates with AMP-activated protein kinase (AMPK) and folliculin (FLCN). The protein also has a role in the O6-methylguanine-induced apoptosis signaling pathway.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

표적 설명

FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship. Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.

결합

The action of this antibody can be blocked using blocking peptide SBP3500010.

물리적 형태

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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관련 제품

제품 번호
설명
가격

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O6-methylguanine-induced apoptosis.
Sano S
Biochemical and Biophysical Research Communications (2013)
A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA.
Komori K
Oncogene (2009)
Leeanna El-Houjeiri et al.
The Journal of clinical investigation, 131(22) (2021-11-16)
Growing tumors exist in metabolically compromised environments that require activation of multiple pathways to scavenge nutrients to support accelerated rates of growth. The folliculin (FLCN) tumor suppressor complex (FLCN, FNIP1, FNIP2) is implicated in the regulation of energy homeostasis via

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