SAB4200129

Anti-Phospholipase A2 (iPLA2) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

• 동의어(들): Anti-CaI-PLA2, Anti-GVI, Anti-INAD1, Anti-IPLA2-VIA, Anti-PARK14, Anti-PLA2, Anti-PLA2G6, Anti-PNPLA9, Anti-Phospholipase A2, group VI (cytosolic, calcium-independent), Anti-iPLA2
• MDL number: MFCD00803786
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: ~85 kDa (and ~95 kDa human iPLA2 and ~95 kDa mouse and rat iPLA2.)
• 종 반응성: human, mouse, rat
• 농도: ~1.5 mg/mL
• 기술: western blot: 1.5-3.0 μg/mL using using extracts of HEK-293T cells overexpressing human iPLA₂, RAW264 cell lysates and rat pancreas extracts (S1 fraction).
• UniProt 수납 번호: O60733
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... PLA2G6(8398) ; mouse ... pla2g6(53357) ; rat ... pla2g6(360426)

설명

일반 설명

Calcium-independent phospholipase A2 (iPLA2) belongs to the group six of phospholipase A2 (PLA2) enzymes. The protein is encoded by the gene mapped to human chromosome 22q13.1. iPLA2 is an intracellular enzyme. It is present both in the cytosol and in membrane fractions. The encoded protein contains 752 amino acids and has a mass of 85kDa. It is characterized with a eight ankyrin repeats and a catalytic domain.

애플리케이션

Anti-Phospholipase A2 (iPLA2) antibody produced in rabbit has been used in western blotting.

생화학적/생리학적 작용

Calcium-independent phospholipase A2 (iPLA2) in the absence of Ca²⁺, catalyzes the hydrolysis of the Sn-2 ester bond in phospholipids to produce free fatty acids and lysophospholipids. iPLA2 might play an essential role in activating the receptor-mediated signaling pathway. Additionally, it also yields precursors for bioactive compounds such as eicosanoid and platelet-activating factor. The encoded protein performs housekeeping role in phospholipid remodeling.

물리적 형태

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable