추천 제품
생물학적 소스
mouse
Quality Level
결합
unconjugated
항체 형태
purified from hybridoma cell culture
항체 생산 유형
primary antibodies
클론
TN-17, monoclonal
형태
buffered aqueous solution
분자량
antigen ~170 kDa
종 반응성
human
농도
~1.0 mg/mL
기술
indirect immunofluorescence: 2.5-5.0 μg/mL using PC3 cells.
western blot: 0.5-1.0 μg/mL using extracts of SW-620 cells.
동형
IgG1
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... TNS3(64759)
일반 설명
Monoclonal Anti-Tensin 3 (mouse IgG1 isotype) is derived from the hybridoma TN-17 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to an internal sequence of human Tensin 3. Tensins are multidomain proteins that are characterized with homologous C1, protein phosphatases (PTPases) , C2, Src homology 2 (SH2) domains and pTyr-binding (PTB) domains.
Tensin 3 (TNS3) is encoded by the gene mapped to human chromosome 7p12.3. TNS3 transcript is expressed at high level in thyroid and at moderate level in placenta. In addition, the protein is also expressed at minimal levels in brain, heart, lung, liver, pancreas, kidney, skeletal muscle, white blood cells and prostate. TNS3 is a member of tensin protein family.
면역원
synthetic peptide corresponding to an internal sequence of human Tensin 3, conjugated to KLH. The isotype is determined using a double diffusion immunoassay using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).
애플리케이션
Monoclonal Anti-Tensin 3 antibody produced in mouse has also been used in immunofluorescence.
Monoclonal Anti-Tensin 3 antibody produced in mouse has been used in western blotting.
생화학적/생리학적 작용
Tensin 3 (TNS3) plays a vital role in stimulation of epidermal growth factor (EGF) signaling pathway. The encoded protein supports fundamental role of thyroid hormone in normal thyroid tissues. Decreased expression of the gene leads to development of human renal cell carcinoma (RCC).
Tensin 3 facilitates cell migration and tumorigenesis in cell lines from advanced lung cancer, breast cancer and melanoma. In these cell lines, The protein is phosphorylated by Src in its SH2 domain, leading to tumorigenesis and metastasis, implicating tensin 3 as an oncoprotein regulated by Src.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Epidermal Growth Factor Modulates Tyrosine Phosphorylation of a Novel Tensin Family Member, Tensin311Supported in part by the Shriners Hospitals Research Award and NIH CA102537.
Molecular Cancer Research (2004)
Tensin3 is a novel thyroid-specific gene
Journal of Molecular Endocrinology, 36, R1-R8 (2008)
Increased expression levels of tensin3 mRNA in thyroid functional adenomas as compared to non-functioning adenomas.
Experimental and Clinical Endocrinology & Diabetes, 117, 191-193 (2009)
CpG dinucleotide-specific hypermethylation of the TNS3 gene promoter in human renal cell carcinoma
Epigenetics, 8, 739-747 (2013)
Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3
Scientific Reports, 7, 8710-8710 (2017)
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