SAB4300255

Anti-phospho-NTRK2 (pTyr⁵¹⁵) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-GP145-TrkB antibody produced in rabbit, Anti-TRKB antibody produced in rabbit, Anti-neurotrophic tyrosine kinase, receptor, type 2 antibody produced in rabbit
• MDL number: MFCD01092509
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: ~140 kDa
• 종 반응성: mouse, rat, human
• 농도: 1 mg/mL
• 기술: indirect immunofluorescence: 1:100-1:200
• 동형: IgG
• 면역원 서열: (P-Q-Y-PF-G)
• NCBI 수납 번호: NP_001007098.1
• UniProt 수납 번호: Q16620
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pTyr515)
• 유전자 정보: human ... NTRK2(4915)

설명

일반 설명

NTRK2 (neurotrophic tyrosine kinase receptor type 2) is also known as TRKB (tropomyosin receptor kinase B). It belongs to the Trk family of neurotrophin receptors. It is located on chromosome 9q21.32.

면역원

Peptide sequence around phosphorylation site of tyrosine 515 (P-Q-Y(p)-F-G), according to the protein NTRK2.

애플리케이션

Anti-phospho-NTRK2 (pTyr515) antibody has been used in western blotting.

생화학적/생리학적 작용

In NB (neuroblastoma), NTRK2 (neurotrophic tyrosine kinase receptor type 2) controls the favorable and unfavorable clinical actions. It also controls the roles of glutamate receptor and synaptic plasticity in the amygdala .

특징 및 장점

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표적 설명

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

물리적 형태

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable