생물학적 소스
rabbit
Quality Level
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
80 kDa
종 반응성
human
농도
1.0 mg/mL
기술
western blot: 1:500-1:1000 (Cell Lysate)
동형
IgG
수납 번호(accession number)
NP_002728.1.
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
phosphorylation (pTyr657)
유전자 정보
human ... PRKCA(5578)
일반 설명
Protein kinase C α (PRKCA) is encoded by the gene mapped to human chromosome 17q24.2. The encoded protein is a member of the serine/threonine-specific protein kinase family.
특이성
The antibody detects endogenous levels of PKC α only when phosphorylated at tyrosine 658.
면역원
Peptide sequence around phosphorylation site of tyrosine 658(F-S-Y(p)-V-N) derived from Human PKC α.
생화학적/생리학적 작용
Protein kinase C α (PRKCA) is a serine-threonine kinase. It is associated with tumorigenesis, invasion, apoptosis, differentiation, angiogenesis and metastasis. Downregulation of PKCA inhibits the invasion of urinary bladder, colon, renal cell, breast carcinomas, multiple myeloma, glioma and endometrial cancer cells. In endothelial cells, PRKCA-mediated phosphorylation of TRPC1 (transient receptor potential cation channel subfamily C member 1) regulates store operated Ca2+ entry.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Identification of a Novel, Recurrent SLC44A1?PRKCA Fusion in Papillary Glioneuronal Tumor
Bridge JA, et al.
Brain Pathology, 23, 121-128 (2013)
PKC? promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness.
Vaskovicova K, et al.
BMC Cancer (2015)
Reduction of protein kinase C α (PKC-α) promote apoptosis via down-regulation of Dicer in bladder cancer.
Jiang Z, et al.
Journal of Cellular and Molecular Medicine, 19, 1085-1093 (2015)
Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells.
Ahmmed GU, et al.
The Journal of Biological Chemistry, 279, 20941-20949 (2004)
MZF-1/Elk-1 Complex Binds to Protein Kinase C? Promoter and Is Involved in Hepatocellular Carcinoma.
Yue CH, et al.
PLoS ONE, 10 (2015)
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