추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 52 kDa
종 반응성
human, mouse
농도
~1 mg/mL
기술
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... WAS(7454)
일반 설명
Anti-WASP Antibody detects endogenous levels of total WASP protein.
WASP (Wiskott-Aldrich syndrome protein) codes for a 65 kDa protein, localized to the cytoplasm. The WASP gene is mapped to human chromosome Xp11.23.
면역원
The antiserum was produced against synthesized peptide derived from human WASP.
Immunogen Range: 256-305
Immunogen Range: 256-305
생화학적/생리학적 작용
WASP (Wiskott-Aldrich syndrome protein) is regarded as a scaffold protein that integrates cell surface signals to actin cytoskeleton. WASP gene regulates actin polymerization, contributing to T-cell activation and migration. Neural WASP is known to regulate a variety of cellular processes including pathogen infection, vesicle trafficking, invadopodium formation and growth, and neurite extension. Mutation in this gene causes WAS, a X-linked recessive immunodeficiency disorder.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
X-Linked Syndrome of Polyendocrinopathy, Immune Dysfunction, and Diarrhea Maps to Xp11.23-Xq13.3
Bennett CL, et al.
American Journal of Human Genetics, 66(2), 461-468 (2000)
Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion
Frugtniet BA, et al.
BMC Cancer, 17(1), 224-224 (2017)
Novel WASP mutation in a patient with Wiskott-Aldrich syndrome: Case report and review of the literature.
Eghbali M, et al.
Allergologia et Immunopathologia, 44(5), 450-454 (2016)
Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α
Jain N, et al.
Scientific Reports, 5, 15031-15031 (2015)
Sudha Kumari et al.
The EMBO journal, 39(5), e102783-e102783 (2020-01-03)
When migratory T cells encounter antigen-presenting cells (APCs), they arrest and form radially symmetric, stable intercellular junctions termed immunological synapses which facilitate exchange of crucial biochemical information and are critical for T-cell immunity. While the cellular processes underlying synapse formation
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