SBR00024

Trimethoprim Ready Made Solution

25 mg/mL in DMSO

• 동의어(들): Trimethoprim Ready Made Solution
• 실험식(Hill 표기법): C₁₄H₁₈N₄O₃
• Molecular Weight: 290.32
• UNSPSC 코드: 51285203
• NACRES: NA.76

속성

• 생물학적 소스: synthetic
• 분석: ≥98% (HPLC)
• 형태: liquid
• 농도: 25 mg/mL in DMSO
• 색상: colorless to faint yellow
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• 동작 모드: DNA synthesis | interferes; enzyme | inhibits
• 저장 온도: −20°C
• InChI: 1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18
• InChI key: IEDVJHCEMCRBQM-UHFFFAOYSA-N

설명

일반 설명

Trimethoprim, an aminopyrimidine antibiotic belonging to the methoxybenzenes group, exhibits activity against a broad spectrum of both gram-negative and gram-positive aerobic bacteria. As a synthetic derivative of pyrimidine, it plays a multifaceted role as an inhibitor, xenobiotic, and allergen, featuring antibacterial, diuretic, and antiprotozoal properties. Trimethoprim selectively targets dihydrofolate reductase (DHFR), diminishing the levels of tetrahydrofolate that supply one-carbon units crucial for biosynthesis processes, including nucleotides, proteins, and panthotenate, especially in prokaryotic microorganisms.

Additionally, it is frequently employed in combination with sulfamethoxazole (sc-208405) to effectively inhibit the growth of Staphylococcus aureus, functioning as a dihydrofolate reductase inhibitor. This versatile compound finds applications in metabolomics, cell biology, and biochemical research.

애플리케이션

Trimethoprim is used at a final concentration of ~4μg/mL for antibacterial activty.

생화학적/생리학적 작용

Mode of Action: Trimethoprim is an inhibitor of bacterial dihydrofolate reductase (DHFR), interfering with the conversion of dihydrofolate (DHF) to tetrahydrofolate (THF). THF is an essential precursor in the thymidine synthesis pathway, interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim′s affinity for bacterial DHFR is several thousand times greater than its affinity for human DHFR.

Activity Spectrum: Effective against Gram-negative bacteria, Gram-positive bacteria, and mycobacteria

Some of the pathogens that trimethoprim can be effective against include:

• Escherichia coli (E. coli)
• Staphylococcus aureus (including methicillin-resistant Staphylococcus aureus or MRSA)
• Streptococcus pneumoniae
• Haemophilus influenzae
• Enterococcus faecalis
• Klebsiella species
• Proteus species

특징 및 장점

• High-quality antibiotic suitable for multiple research applications
• Ideal for Cell Biology, Metabolomics, and Biochemical research.

기타 정보

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안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): 188.6 °F
• Flash Point (°C): 87 °C