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Merck
모든 사진(1)

주요 문서

SCP0060

Sigma-Aldrich

CGRP II 8-37 human / β CGRP 8-37 human

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C138H229N43O38S1
Molecular Weight:
3130.63
UNSPSC 코드:
12352200
NACRES:
NA.32

분석

≥95% (HPLC)

양식

lyophilized

구성

Peptide Content, ≥75%

저장 조건

protect from light

저장 온도

−20°C

Amino Acid Sequence

Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2

애플리케이션

β-Calcitonin gene related peptide (β-CGRP) regulates cardiovascular homeostasis and nociception via G-coupled protein receptor (GCPR) calcitonin receptor-like receptor (CALCRL).
CGRP II 8-37 is used as a CGRP receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
MF0413

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문서 라이브러리 방문

Joseph J Lynch et al.
European journal of pharmacology, 623(1-3), 96-102 (2009-09-22)
The triptans, serotonin 5-HT(1B/1D) receptor agonists exemplified by sumatriptan, are a mainstay migraine therapy but have class labeling contraindicating their use in patients with coronary artery disease. Triptans constrict human coronary artery in vitro, and there are case reports of
Toomas Talme et al.
Journal of neuroimmunology, 196(1-2), 60-66 (2008-04-22)
CGRP significantly stimulated migration of non-activated and anti-CD3 activated T lymphocytes into a collagen matrix when present inside the collagen, whereas somatostatin-14, NPY, substance P, VIP, beta-endorphin and metenkephalin had no or little effect. The CGRP antagonist CGRP 8-37 abrogated
Vince T Nguyen et al.
Peptides, 33(1), 77-82 (2011-11-24)
Cardiac epinephrine and calcitonin gene-related peptide (CGRP) are produced by intrinsic cardiac adrenergic cells (ICA cells) residing in human and animal hearts. ICA cells are neuroparicine cells expressing δ-opioid receptors (DOR). We hypothesized that δ-opioid stimulation of ICA cells enhances
Jean-Olivier Zirimwabagabo et al.
Journal of medicinal chemistry, 64(6), 3299-3319 (2021-03-06)
Class B G-protein-coupled receptors (GPCRs) remain an underexploited target for drug development. The calcitonin receptor (CTR) family is particularly challenging, as its receptors are heteromers comprising two distinct components: the calcitonin receptor-like receptor (CLR) or calcitonin receptor (CTR) together with
I-Ching Hou et al.
Peptides, 30(12), 2228-2232 (2009-09-02)
We found that beta-lactotensin (His-Ile-Arg-Leu), which has been isolated as an ileum-contracting peptide from chymotrypsin digest of bovine beta-lactoglobulin, dose-dependently suppresses food intake after intracerebroventricular (i.c.v.) or intraperitoneal administration at a dose of 40 nmol/mouse or 100mg/kg, respectively, in fasted
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