SML0305

3-Deazaneplanocin A hydrochloride

≥97% (HPLC)

• 동의어(들): (-)-1-[(1R,4R,5S)-3-(Hydroxymethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aminoimidazo[4,5-c]pyridine hydrochloride, DZNep hydrochloride
• 실험식(Hill 표기법): C₁₂H₁₄N₄O₃ · HCl
• CAS Number: 120964-45-6
• Molecular Weight: 298.73
• MDL number: MFCD18782644
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825310
• NACRES: NA.77

속성

• 분석: ≥97% (HPLC)
• 형태: powder
• 광학 활성: [α]/D -88 to -108°, c = 0.1 in water
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: ≥5 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: Cl.Nc1nccc2n(cnc12)[C@@H]3C=C(CO)[C@@H](O)[C@H]3O
• InChI: 1S/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H/t8-,10-,11+;/m1./s1
• InChI key: UNSKMHKAFPRFTI-FDKLLANESA-N

설명

일반 설명

3-Deazaneplanocin A hydrochloride is a carbocyclic analog of adenosine. It has antimetastatic property. It is used to treat Ebola virus disease, gastric cancer, myeloma and lymphoma.

애플리케이션

3-Deazaneplanocin A hydrochloride has been used to examine the potential involvement of autophagy and apoptosis in colorectal cancer (CRC) cells.

3-Deazaneplanocin A hydrochloride has been used to test its effect on ovarian tumor progression. It has also been used as a S-adenosyl homocysteine hydrolase (SAH) inhibitor in c33A2 cells.

생화학적/생리학적 작용

3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.

특징 및 장점

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable