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Merck
모든 사진(1)

주요 문서

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SML0346

Sigma-Aldrich

Alosetron hydrochloride

≥98% (HPLC)

동의어(들):

2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C17H18N4O·HCl
CAS Number:
122852-69-1
Molecular Weight:
330.81
MDL number:
MFCD09028027
UNSPSC 코드:
12352200
PubChem Substance ID:
329825350
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

형태

powder

저장 조건

desiccated

색상

white to beige

solubility

H2O: ≥5 mg/mL at warmed

저장 온도

2-8°C

SMILES string

CN1C2=C(C=CC=C2)C3=C1CCN(CC4=C(C)N=CN4)C3=O.Cl

InChI

1S/C17H18N4O.ClH/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2;/h3-6,10H,7-9H2,1-2H3,(H,18,19);1H

InChI key

FNYQZOVOVDSGJH-UHFFFAOYSA-N

유전자 정보

human ... HTR3A(3359)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

생화학적/생리학적 작용

Alosetron is a potent and highly selective antagonist of serotonin 5-HT3 receptors, nonselective cation channels found predominantly in the enteric nervous system of the gastrointestinal tract. These receptors are involved in the regulation of visceral pain, colonic transit and GI secretions that can contribute to the pathophysiology of irritable bowel syndrome (IBS). Alosetron is used clinically for treatment of women with severe diarrhea-predominant IBS.

픽토그램

Skull and crossbones
GHS06

신호어

Danger

유해 및 위험 성명서

H301,H319,H412

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Larry D Lynd et al.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 13(4), 411-417 (2009-09-12)
There is consensus that a more transparent, explicit, and rigorous approach to benefit-risk evaluation is required. The objective of this study is to evaluate the incremental net benefit (INB) framework for undertaking quantitative benefit-risk assessment by performing a quantitative benefit-risk
F Reed Johnson et al.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 13(4), 418-423 (2010-03-17)
The Food and Drug Administration, currently, is exploring quantitative benefit-risk methods to support regulatory decision-making. A scientifically valid method for assessing patients' benefit-risk trade-off preferences is needed to compare risks and benefits in a common metric. The study aims to
Alexander C Ford et al.
The American journal of gastroenterology, 104(7), 1831-1843 (2009-05-28)
Irritable bowel syndrome (IBS) is a chronic functional disorder. 5-Hydroxytryptamine (5-HT) is a key modulator of gastrointestinal sensorimotor function. Many patients have IBS that can be difficult to treat, which has led to the development of newer agents, such as
Clinical practice. Irritable bowel syndrome.
Emeran A Mayer
The New England journal of medicine, 358(16), 1692-1699 (2008-04-19)
James H Lewis
Drug safety, 34(7), 545-565 (2011-06-15)
Ischaemic colitis (IC) is the most common form of ischaemic injury to the gastrointestinal (GI) tract. IC typically presents with the sudden onset of lower abdominal pain, cramping and rectal bleeding, and is usually self-limited with low morbidity, although it
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