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Merck
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주요 문서

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SML0423

Sigma-Aldrich

ML194

≥98% (HPLC)

동의어(들):

1-(2,4-Difluorophenyl)-5-[[2-[[(1,1-dimethylehyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylic acid methyl ester, CID-9581011, CID9581011, Methyl 5-[(E)-(tert-butylcarbamothioylhydrazinylidene)methyl]-1-(2,4-difluorophenyl)pyrazole-4-carboxylate

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C17H19F2N5O2S
CAS Number:
264233-05-8
Molecular Weight:
395.43
MDL number:
MFCD00111058
UNSPSC 코드:
12352200
PubChem Substance ID:
329825418
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

powder

저장 조건

protect from light

색상

white to beige

solubility

DMSO: 15 mg/mL (clear solution)

저장 온도

−20°C

SMILES string

COC(=O)c1cnn(-c2ccc(F)cc2F)c1\C=N\NC(=S)NC(C)(C)C

InChI

1S/C17H19F2N5O2S/c1-17(2,3)22-16(27)23-20-9-14-11(15(25)26-4)8-21-24(14)13-6-5-10(18)7-12(13)19/h5-9H,1-4H3,(H2,22,23,27)/b20-9+

InChI key

CYNLZIBKERMMOA-AWQFTUOYSA-N

생화학적/생리학적 작용

ML194 (CID9581011) is an antagonist of GPR35, a GPRC receptor expressed in nervous system tissue, in the GI tract particularly in pancreas and small intestine, followed by colon, spleen, and immune cells, and also expressed in gastric carcinomas. GPR35 is being investigated for potential therapeutic importance in a variety of areas including pain, hypertension, cancer, diabetes and asthma. ML194 is more membrane penetrant and more potent than earlier synthetic antagonists, with an IC50 of 160nM. ML194 was also found to rescue the cell-surface expression of mutant GPR35 receptors, likely acting as a pharmacological chaperone to alter the misfolded receptor structure.
ML194 is an antagonist of GPR35.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
0000242575
0000207769
082M4611V

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Xiao Zheng et al.
Brain, behavior, and immunity, 79, 244-255 (2019-02-23)
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