SML0848

LM22A-4

≥98% (HPLC)

• 동의어(들): N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
• 실험식(Hill 표기법): C₁₅H₂₁N₃O₆
• CAS Number: 37988-18-4
• Molecular Weight: 339.34
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to beige
• solubility: H₂O: 2 mg/mL, clear (warmed)
• 저장 온도: 2-8°C
• InChI: 1S/C15H21N3O6/c19-4-1-16-13(22)10-7-11(14(23)17-2-5-20)9-12(8-10)15(24)18-3-6-21/h7-9,19-21H,1-6H2,(H,16,22)(H,17,23)(H,18,24)
• InChI key: RGWJKANXFYJKHN-UHFFFAOYSA-N

설명

애플리케이션

LM22A-4 has been used as a component of dissociation medium for mouse embryonic stem cells (mESC) and human embryonic stem (hESC) aggregates.

생화학적/생리학적 작용

LM22A-4 is a non-peptide and shares similarity with brain-derived neurotrophic factor (BDNF), especially in the loop2 region. It improves oligodendroglia density and favors myelin repair. LM22A-4 elevates the expression of protein kinase B (PKB or Akt) and extracellular signal-regulated kinases (ERKs). LM22A-4 elicits neuroprotection in spinal cord injury (SCI) by deregulating the cleaved-caspase-3 and favoring B-cell lymphoma 2(Bcl-2) expression.

LM22A-4 is a partial agonist of TrkB, a brain-derived neurotrophic factor (BDNF) receptor. In binding assays, LM22A-4 displaces BDNF with an IC₅₀ of 47 nM. The compound restores TrkB phosphorylation and respiratory function in a mouse model of Rett syndrome.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable