SML1043

KC7F2

≥98% (HPLC)

• 동의어(들): N,N′-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide
• 실험식(Hill 표기법): C₁₆H₁₆Cl₄N₂O₄S₄
• CAS Number: 927822-86-4
• Molecular Weight: 570.38
• MDL number: MFCD22683809
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825637
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 20 mg/mL, clear
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: ClC1=CC=C(Cl)C=C1S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O
• InChI: 1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2
• InChI key: REQLACDIZMLXIC-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

KC7F2 is a cell permeable potent HIF-1 pathway inhibitor. KC7F2 inhibits the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2 (MMP2), enolase 1, and endothelin 1. KC7F2 suppresses the protein accumulation of HIF-1? in cancer cell lines by inhibition of its protein synthesis at the translation level. KC7F2 is preferentially cytotoxicity to cancer cells, an effect that is increased in hypoxia.

특징 및 장점

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기타 정보

air sensitive

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable