SML1169
Pitstop 2
≥98% (HPLC), powder, clathrin-mediated endocytosis inhibitor
동의어(들):
N-[5-[(4-Bromophenyl)methylene]-4,5-dihydro-4-oxo-2-thiazolyl]-1-naphthalenesulfonamide, Pitstop-2
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C20H13BrN2O3S2
CAS Number:
Molecular Weight:
473.36
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
제품명
Pitstop 2, ≥98% (HPLC)
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to light brown
solubility
DMSO: 20 mg/mL, clear
저장 온도
−20°C
애플리케이션
Pitstop 2 has been used as an inhibitor of clathrin-mediated endocytosis.
생화학적/생리학적 작용
Pitstop 2 also has an ability to breakdown the nuclear pore complex (NPC) permeability barrier and decrease importin β binding along with alteration of the NPC ultrastructure. Pitstop 2 is also involved in the inhibition of platelet activation, platelet aggregation and secretion.
Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis that acts via blocking ligand access to the clathrin terminal domain. Pitstop 2 selectively inhibits clathrin-mediated HIV entry and stalls clathrin-coated pit (CCP) dynamics.
Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Clathrin-mediated integrin ?IIb?3 trafficking controls platelet spreading
Gao W, et al.
Platelets, 1-12 (2017)
Clathrin inhibitor Pitstop-2 disrupts the nuclear pore complex permeability barrier
Liashkovich I, et al.
Scientific Reports, 5, 9994-9994 (2015)
Muhammad Asam Riaz et al.
Journal of proteomics, 227, 103918-103918 (2020-07-28)
Bacterial insecticidal proteins, such as the Bin toxin from Lysinibacillus sphaericus, could be used more extensively to control insecticide resistant mosquitoes. This study was aimed at identification of mosquito cell proteins binding Bin toxin. Results showed that purified toxin was
Leucine-rich repeat-containing G protein?coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein
Zhang N, et al,
The Journal of Biological Chemistry, 292(40), 16527-16538 (2017)
Meagan M Postema et al.
Molecular biology of the cell, 30(19), 2515-2526 (2019-08-08)
Apical microvilli are critical for the homeostasis of transporting epithelia, yet mechanisms that control the assembly and morphology of these protrusions remain poorly understood. Previous studies in intestinal epithelial cell lines suggested a role for the F-BAR domain protein PACSIN2
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