SML1270

YZ9

≥98% (HPLC)

• 동의어(들): 3-Carbethoxy-7-hydroxycoumarin, 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic acid ethyl ester
• 실험식(Hill 표기법): C₁₂H₁₀O₅
• CAS Number: 6093-71-6
• Molecular Weight: 234.20
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• 저장 온도: −20°C
• SMILES string: [o]1c2c(cc([c]1=O)C(=O)OCC)ccc(c2)O
• InChI: 1S/C12H10O5/c1-2-16-11(14)9-5-7-3-4-8(13)6-10(7)17-12(9)15/h3-6,13H,2H2,1H3
• InChI key: IETDBZQIWIJQJG-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

PFKFB3 inhibitor

YZ9 is a 5, 6, 7, 8-tetrahydroxy-2-(4-hydroxyphenyl) chromen-4-one (N4A) inhibitor.

YZ9 is a potent inhibitor of PFKFB3 (6-phosphfructo-2-kinase/fructose-2,6-bisphosphatase) with an IC₅₀ = 183 nM. PFKFB3 is over expressed in many cancers and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YZ9 dose dependently inhibits proliferation of HeLa cells.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable