SML1668
Tipifarnib
≥98% (HPLC)
동의어(들):
(R)-(+)-R 115777, 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone, R115777
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C27H22Cl2N4O
CAS Number:
Molecular Weight:
489.40
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
광학 활성
[α]/D 17 to 24°, c = 1 in methanol
색상
white to beige
solubility
DMSO: 10 mg/mL, clear
저장 온도
−20°C
SMILES string
CN(C1=CC=C([C@](C2=CN=CN2C)(N)C3=CC=C(Cl)C=C3)C=C1C(C4=CC=CC(Cl)=C4)=C5)C5=O
InChI
1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1
InChI key
PLHJCIYEEKOWNM-HHHXNRCGSA-N
관련 카테고리
일반 설명
Pre-clinical studies show that tipifarnib has antiproliferative effects on pancreatic cancer cell lines at clinically relevant concentrations (concentration that inhibits 50% growth [IC50] from 9.5 to 500 nmol/L). It also exhibits marked growth retardation and antiangiogenic effects in a pancreatic cancer xenograft model.
생화학적/생리학적 작용
Orally active and potent farnesyltransferase (FTase) inhibitor
Tipifarnib (R115777) is an orally active and potent farnesyltransferase (FTase) inhibitor that exhibits potent anti-tumorigenic effects. Tipifarnib mechanism of action is not fully understand.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer.
Van E C, et al.
Journal of Clinical Oncology, 22(8), 1430-1438 (2004)
Madeleine Dorsch et al.
Cell reports, 37(8), 110056-110056 (2021-11-25)
Statins are among the most commonly prescribed drugs, and around every fourth person above the age of 40 is on statin medication. Therefore, it is of utmost clinical importance to understand the effect of statins on cancer cell plasticity and
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