SML1833
ML385
≥98% (HPLC), powder, Nrf2 transcription factor inhibitor
동의어(들):
N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C29H25N3O4S
CAS Number:
Molecular Weight:
511.59
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
![[D-Trp7, Ala8, D-Phe10]-α-Melanocyte Stimulating Hormone Amide Fragment 6-11 ≥97% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/137/006/013a88e0-770d-44fb-8438-97b5d2d79d5c/640/013a88e0-770d-44fb-8438-97b5d2d79d5c.png)
제품명
ML385, ≥98% (HPLC)
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 10 mg/mL, clear
저장 온도
2-8°C
SMILES string
O=C(NC1=NC(C2=CC=C(N(C(C3=C(C)C=CC=C3)=O)CC4)C4=C2)=C(C)S1)CC5=CC(OCO6)=C6C=C5
InChI
1S/C29H25N3O4S/c1-17-5-3-4-6-22(17)28(34)32-12-11-20-15-21(8-9-23(20)32)27-18(2)37-29(31-27)30-26(33)14-19-7-10-24-25(13-19)36-16-35-24/h3-10,13,15H,11-12,14,16H2,1-2H3,(H,30,31,33)
InChI key
LINHYWKZVCNAMQ-UHFFFAOYSA-N
관련 카테고리
생화학적/생리학적 작용
ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1, a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking NRF2 transcriptional activity. Much research has been done on activating Nrf2 because it induces cytoprotective antioxidant genes. However, some cancer cells may use Nrf2 similarly for their survival. Nrf2 is overexpressed in certain cancers such as non-small cell lung cancer (NSCLC) often due to loss of function mutations in KEAP1, which targets Nrf2 for proteasomal degradation. ML385 was found to have anti-tumor activity with specificity and selectivity for NSCLC cells with KEAP1 mutations.
ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
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