SML3900

955, CDK9 PROTAC trifluoroacetate

≥98% (HPLC)

• 동의어(들): (E)-N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(2-(4-(2-(2,6-dimethoxy-4-(3-oxo-3-(6-oxo-3,6-dihydropyridin-1(2H)-yl)prop-1-en-1-yl)phenoxy)ethyl)piperazin-1-yl)-2-oxoethyl)piperidine-4-carboxamide trifluoroacetate, PL-SNS-032 conjugate 955 trifluoroacetate
• 실험식(Hill 표기법): C₄₁H₅₃N₇O₈S₂ · xC₂HF₃O₂
• Molecular Weight: 836.03 (free base basis)
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: -10 to -25°C

설명

생화학적/생리학적 작용

955 CDK9 PROTAC is a cell penetrant conjugate of the CDK9 inhibitor SNS-032 with new recruiter of the E3 ligase KEAP1 piperlongumine that potently degrades CDK9 in MOLT4 cells. Similarly, to THAL-SNS-032, 955 induces CDK10 degradation. 955 exhibits potent antiproliferative activity in several prostate cancer cell lines including LNCaP, 22RV1, PC3 and DU145 cells.

Cell penetrant, potent and selective CDK9 degrader

주의사항

Hygroscopic

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable