추천 제품
생물학적 소스
human
재조합
expressed in E. coli
분석
≥98% (HPLC)
≥98% (SDS-PAGE)
양식
lyophilized
분자량
12.6 kDa
포장
pkg of 10 μg
기술
cell culture | mammalian: suitable
불순물
<0.1 EU/μg endotoxin, tested
색상
white to off-white
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... IL13(3596)
일반 설명
IL13 (interleukin 13) is a classic cytokine produced by Th2 (T-helper) cells. This gene is localized to human chromosome 5q31, and is composed of four exons and three introns.
Recombinant human IL-13 is a 12.5 kDa protein consisting of 114 amino acid residues.
Recombinant human IL-13 is a 12.5 kDa protein consisting of 114 amino acid residues.
애플리케이션
IL-13 variant human has been used for the treatment of THP1 monocytes, along with with IL-4 and phorbol myristate acetate (PMA), to study the ability of SFN (sulforaphane) to induce THP1 differentiation into M2 macrophage cells.
생화학적/생리학적 작용
IL13 (interleukin 13) is up-regulated during parasitic infections, and participates in host′s protective immunity against Schistosoma japonicum. This protein promotes eosinophil activation resulting in elevated specific IgE against adult and larval antigens. During acute infection it promotes egg expulsion through increased intestinal contractility. It acts as a liver protective agent where it promotes formation of liver granulomas in a CD4+ T cell-mediated manner, which results in liver fibrosis. In airway disorders, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis lung disease, IL13 promotes the formation of airway goblet cells, resulting in excess mucus secretion, which in turn, is regulated by IL13-activated autophagy. In adult subjects with ever-asthma, SNP (single nucleotide polymorphism) rs848 in this gene is linked with symptom severity.
서열
MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN
물리적 형태
Lyophilized from 10 mM Sodium Citrate, pH 4.0.
재구성
Centrifuge the vial prior to opening. Reconstitute in 20 mM Acetic Acid to a concentration of 0.1-0.5 mg/ml. Note: Allow the reconstituted vial to sit at 4°C for at >2 hours before use. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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이미 열람한 고객
An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma.
Accordini S et al
PLoS ONE, 11(3), e0151292-e0151292 (2016)
Sulforaphane regulates phenotypic and functional switching of both induced and spontaneously differentiating human monocytes.
Pal S and Konkimalla VB
International Immunopharmacology, 35, 85-98 (2016)
IL13 activates autophagy to regulate secretion in airway epithelial cells.
Dickinson JD et al
Autophagy, 12(2), 397-409 (2016)
M Wills-Karp et al.
Science (New York, N.Y.), 282(5397), 2258-2261 (1998-12-18)
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4(+) T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a
Xin Long et al.
PloS one, 10(8), e0135360-e0135360 (2015-08-11)
The aim of this study was to determine whether two polymorphisms in the gene encoding IL13 previously associated with Schistosoma hematobium (S. hematobium) and S. mansoni infection are associated with S. japonicum infection. Single nucleotide polymorphisms (SNPs) rs1800925 (IL13/-1112C>T) and
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