추천 제품
생물학적 소스
human
재조합
expressed in E. coli
분석
≥98% (HPLC)
≥98% (SDS-PAGE)
형태
lyophilized
분자량
~27.8 kDa
포장
pkg of 10 μg
불순물
endotoxin, tested
NCBI 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... MSTN(2660)
일반 설명
MSTN (myostatin) belongs to the transforming growth factor-β (TGF β) superfamily containing numerable homologous cytokine proteins. This gene is expressed in skeletal muscle, and codes for a precursor protein composed of an N-terminal leader peptide, a pro-peptide domain, and a C-terminal domain. This precursor protein is proteolytically cleaved by bone morphogenetic protein 1 (BMP-1) at a conserved four amino acid RSRR site to produce the 13kDa mature protein.
생화학적/생리학적 작용
MSTN (myostatin) functions as a negative modulator of muscle cell development. It functions through forming heteromeric receptor complexes such as with activin type II receptor B (ActRIIB), and with lesser affinity with ActIIA. This interaction results in the recruitment of type I receptors like activin receptor-like kinase 4 (ALK4) or ALK5, leading to the phosphorylation of Smad2 (small mothers against decapentaplegic) and Smad3, which move to the nucleus and suppress myogenesis. In MSTN-null mice, there is delayed skin wound healing due to the increased expression of decorin, an endogenous transforming growth factor-β (TGF β) suppressor. Topical treatment with TGF-β1 restored skin wound healing, suggesting that MSTN agonists might have therapeutic beneficial in skin wound repair.
물리적 형태
Lyophilized without any additives.
재구성
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1 to 1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Myostatin rapid sequence evolution in ruminants predates domestication.
Tellgren A
Molecular Phylogenetics and Evolution, 33, 782-790 (2004)
Myostatin-null mice exhibit delayed skin wound healing through the blockade of transforming growth factor-? signaling by decorin.
Zhang C
American Journal of Physiology. Cell Physiology, 302, 1213-1225 (2012)
Qiqi Yang et al.
Disease models & mechanisms, 12(2) (2019-02-06)
Cancer cachexia affects up to 80% of patients with advanced solid cancer and leads to excessive muscle wasting. Here, using an inducible zebrafish hepatocellular carcinoma (HCC) model driven by oncogenic krasG12V , we observed a progressive muscle-wasting phenotype in adult
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