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Merck
모든 사진(1)

Key Documents

SRP4896

Sigma-Aldrich

TSLP human

recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)

동의어(들):

Thymic Stromal Lymphopoietin

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About This Item

UNSPSC 코드:
51111800
NACRES:
NA.32

생물학적 소스

human

재조합

expressed in E. coli

분석

≥97% (HPLC)
≥97% (SDS-PAGE)

형태

lyophilized

효능

<0.3 ng/mL ED50

분자량

~15.0 kDa

포장

pkg of 20 μg

저장 조건

avoid repeated freeze/thaw cycles

불순물

endotoxin, tested

NCBI 수납 번호

배송 상태

wet ice

저장 온도

−20°C

유전자 정보

human ... TSLP(85480)

일반 설명

Thymic stromal lymphopoietin (TSLP) is a hemopoietic cytokine. It is part of the interleukin-2 (IL-2) cytokine family. It is mainly expressed in the heart, liver and prostate. TSLP is related in its biological activities to interleukin-7 (IL-7) and binds with the heterodimeric receptor complex consisting of interleukin-7 receptor α chain & the TSLP receptor. Recombinant human TSLP produced in Escherichia coli is a single, non-glycosylated polypeptide chain containing 132 amino acids and having a molecular mass of 15kDa.

애플리케이션

TSLP human has been used in immunohistochemistry.

생화학적/생리학적 작용

Thymic stromal lymphopoietin (TSLP) signals throughout a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the interleukin-7 (IL-7) receptor a chain. TSLP impacts myeloid cells and thus induces the discharge of T cell-attracting chemokines from monocytes and increases the growth of CD11c+ dendritic cells. Similar to IL-7, TSLP enhances phosphorylation of signal transducer and activator of transcription 3 and 5 (STAT3 and STAT5), though uses kinases excluding Janus kinases (JAKs) for its activation. TSLP induces the release of T cell-attracting chemokines such as thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) from monocytes and triggers CD11c+ dendritic cells. TSLP activated dendritic cells primes naive T cells to manufacture pro-allergic cytokines such as interleukin-4, interleukin-5, interleukin-13 and tumor necrosis factor-α (TNF-α), whereas down-regulating interleukin-10 and interferon-γ (IFN-γ) play a role in the initiation of allergic inflammation.

물리적 형태

Lyophilized from a concentrated solution (1 mg/ml) containing 130 mM NaCl, and 20 mM sodium phosphate, pH 7.4.

재구성

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in sterile dH2O to a concentration of 0.1 -1 mg/mL and let the lyophilized pellet dissolve completely. This solution can then be diluted into other aqueous buffers.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

The biology of thymic stromal lymphopoietin (TSLP).
Ziegler SF
Advances in Pharmacology, 66, 129-155 (2013)
Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity.
Ying S
Journal of Immunology, 174(12), 8183-8190 (2005)
Unusual Timing of CD127 Expression by Mouse Uterine Natural Killer Cells
Jianhong Zhang
Journal of Leukocyte Biology, 91(3), 417-426 (2012)
Frederique M Moret et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(5), 1176-1184 (2014-05-02)
To determine the levels of thymic stromal lymphopoietin (TSLP) and the numbers of TSLP receptor (TSLPR)-expressing CD1c+ (blood dendritic cell antigen 1-positive) myeloid dendritic cells (MDCs) in the joints as compared with the peripheral blood (PB) of patients with rheumatoid
Chun I Yu et al.
Journal of immunology (Baltimore, Md. : 1950), 193(9), 4335-4343 (2014-09-24)
Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response

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