SRP6147

Ubiquitin Activating Enzyme E1 human

≥95% (SDS-PAGE)

• 동의어(들): AMCX1, POC20, UBA1, UBE1, Ubiquitin E1
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 분석: ≥95% (SDS-PAGE)
• 양식: liquid
• 효능: >3 nM
• 분자량: 118
• 포장: pkg of 50 μg
• NCBI 수납 번호: P22314
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... UBA1(7317)

설명

일반 설명

Research area: Cell Signaling

Ubiquitin activating enzyme 1 (UBA1) or UBE1, is an ubiquitin-activating enzyme. The gene encoding it is localized on human chromosome Xp11.23.

애플리케이션

Ubiquitin Activating Enzyme E1 human has been used in in vitro and in vivo ubiquitination assays.

생화학적/생리학적 작용

Ubiquitin activating enzyme 1 (UBA1) has a role in cellular protein homeostasis. It is the first enzyme utilized in the pathway to conjugate ubiquitin onto target substrates through an ubiquitin-protein isopeptide bond. The C-terminal glycine of an ubiquitin (G76) is initially adenylated in an ATP dependent manner activating it so it can be transferred to the active site cysteine of UBE1 forming an ubiquitin-UBE1 thiolester. With the help of the other enzymes in the ubiquitin conjugation pathway (E2/E3 enzymes) the ubiquitin is transferred to a specific lysine on a target substrate. The protein has been associated with spinal muscular atrophy (SMA) and Huntington′s disease (HD).

물리적 형태

In 50 mM Tris (pH 8.0), 100 mM NaCl and 10% glycerol.

제조 메모

Centrifuge the vial prior to opening.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable