SRP8003

Clusterin (nuclear form) mouse

>90% (SDS-PAGE), recombinant, expressed in E. coli, His tagged, liquid

• 동의어(들): Apolipoprotein J, CLI, Lymphocyte antigen 52 (Ly-52), SGP-2, TRPM-2
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 제품명: Clusterin (nuclear form) mouse, recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)
• 생물학적 소스: mouse
• 재조합: expressed in E. coli
• 태그: His tagged
• 분석: >90% (SDS-PAGE)
• 양식: liquid
• 분자량: ~45 kDa by SDS-PAGE
• 포장: pkg of 50 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 농도: ≥0.2 mg/mL
• 불순물: <1 EU/μg endotoxin, tested
• 색상: clear
• UniProt 수납 번호: Q06890
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: mouse ... Clu(12759)

설명

일반 설명

Clusterin is expressed in all tissues. However, it is strongly expressed in the central nervous system and plasma. Clusterin mainly protects against heat and other stress. It is also referred as chaperone protein and stress-inducible biomarker. Clusterin exists in two isoforms, one is a secretory form and other is a nuclear form. The secreted form of the protein is a 80kDa disulfide-linked heterodimer of α and β subunits (produced by internal cleavage). The alternatively spliced inactive cytosolic form is changed to a truncated mature nuclear isoform via ionizing irradiation.

생화학적/생리학적 작용

Clusterin is involved in tissue remodeling, cell death, lipid transport, complement-associated cell lysis, cancer and neurological damage. It is strongly expressed in Alzheimer′s and treatment-resistant cancer. High levels of clusterin are observed in ischemic heart disease and diabetic conditions. It also protects kidney from fibrosis. Nuclear form of clusterin works as a pro-death signal, and suppresses cell growth and survival. The secreted form of clusterin has extracellular chaperone and anti-apoptotic activities.

물리적 형태

Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.

기타 정보

Mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable