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Merck
모든 사진(1)

주요 문서

T2815

Sigma-Aldrich

Transforming Growth Factor-β2 human

≥97% (electrophoresis), recombinant, expressed in NSO cells, powder, suitable for cell culture

동의어(들):

hTGF-β2, TGF-β2

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About This Item

MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.77

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제품명

Transforming Growth Factor-β2 human, TGF-β2, recombinant, expressed in NSO cells, powder, suitable for cell culture

생물학적 소스

human

Quality Level

재조합

expressed in NSO cells

분석

≥97% (electrophoresis)

양식

powder

효능

0.04 ng/mL ED50

품질

endotoxin tested

분자량

25 kDa

포장

pkg of 10 μg
pkg of 2 μg

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일반 설명

The transforming growth factor-β2 (TGFB2) gene is mapped to human chromosome 1q41.[1] The encoded protein is localized to extracellular matrix.[2] TGF-β2 is a member of the TGF-β superfamily.[3] TGF-β exists in three isoforms (TGF-β1, TGF-β2 and TGF-β3) and are known to share similar structure and function.[4]

애플리케이션

Transforming Growth Factor-β2 human has been used in chondrogenic, adipogenic and osteogenic differentiation of mesenchymal stem cells.[5] It has also been used to induce extracellular matrix accumulation in primary human trabecular meshwork cells and further to study the action of tetramethylpyrazine on the same.[6]

생화학적/생리학적 작용

TGF-β2 is known to stimulate cell growth, differentiation, migration and survival.[7] TGF-β2 acts as a key regulator for immune homeostasis by controlling lymphocyte proliferation, embryogenesis, hematopoiesis and apoptosis.[6] TGF-β is also associated with inflammation and wound healing and is considered as a strong growth inhibitor for keratinocyte cells.[8][9] TGF-β is associated with the process of tumor development, progression and metastasis.[10] TGF-β2 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis.[7] The TGF-β gene is overexpressed in glioma tumors and also in colon cancer, gastric cancer and cervical lesions.[4]
Transforming growth factor-β2 (TGF-β2), like TGF-β1, is produced by many cell types and reported to be most concentrated in mammalian platelets.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.1 mg bovine serum albumin

분석 메모

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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이미 열람한 고객

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Transforming growth factor β (TGF-β) and inflammation in cancer.
Bierie B and Moses HL
Cytokine & Growth Factor Reviews, 21.1, 49-59 (2010)
TGF-β1 and TGF-β2 abundance in liver diseases of mice and men
Dropmann A, et al.
Oncotarget, 7(15), 19499?19518-19499?19518 (2016)
Preliminary Results of Tissue-Engineered Injection Laryngoplasty
Material in a Rabbit Model
Oldenburg MS, et al.
Laryngoscope, 128, 160-167 (2018)
TGF-β2?induced matrix modification and cell transdifferentiation in the human lens capsular bag
Wormstone IM, et al.
Investigative Ophthalmology & Visual Science, 43.7, 2301-2308 (2002)
Michael S Oldenburg et al.
The Laryngoscope, 128(1), 160-167 (2017-09-13)
Design and test a novel biomaterial for injection laryngoplasty aimed to increase the duration of effectiveness of micronized acellular dermis. Animal model. Injection laryngoplasty was performed in three groups (n = 5) of New Zealand White rabbits. Acellular dermis was

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