T2815

Transforming Growth Factor-β2 human

≥97% (electrophoresis), recombinant, expressed in NSO cells, powder, suitable for cell culture

• 동의어(들): hTGF-β2, TGF-β2
• MDL number: MFCD00163957
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• 제품명: Transforming Growth Factor-β2 human, TGF-β2, recombinant, expressed in NSO cells, powder, suitable for cell culture
• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in NSO cells
• 분석: ≥97% (electrophoresis)
• 양식: powder
• 효능: 0.04 ng/mL ED₅₀
• 품질: endotoxin tested
• 분자량: 25 kDa
• 포장: pkg of 10 μg; pkg of 2 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 기술: cell culture | mammalian: suitable
• 불순물: ≤1 EU/μg
• 적합성: suitable for
• UniProt 수납 번호: P61812
• 저장 온도: −20°C
• 유전자 정보: human ... TGFB2(7042) , TGFBR2(7048)

설명

일반 설명

The transforming growth factor-β2 (TGFB2) gene is mapped to human chromosome 1q41. The encoded protein is localized to extracellular matrix. TGF-β2 is a member of the TGF-β superfamily. TGF-β exists in three isoforms (TGF-β1, TGF-β2 and TGF-β3) and are known to share similar structure and function.

애플리케이션

Transforming Growth Factor-β2 human has been used in chondrogenic, adipogenic and osteogenic differentiation of mesenchymal stem cells. It has also been used to induce extracellular matrix accumulation in primary human trabecular meshwork cells and further to study the action of tetramethylpyrazine on the same.

생화학적/생리학적 작용

TGF-β2 is known to stimulate cell growth, differentiation, migration and survival. TGF-β2 acts as a key regulator for immune homeostasis by controlling lymphocyte proliferation, embryogenesis, hematopoiesis and apoptosis. TGF-β is also associated with inflammation and wound healing and is considered as a strong growth inhibitor for keratinocyte cells. TGF-β is associated with the process of tumor development, progression and metastasis. TGF-β2 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. The TGF-β gene is overexpressed in glioma tumors and also in colon cancer, gastric cancer and cervical lesions.

Transforming growth factor-β2 (TGF-β2), like TGF-β1, is produced by many cell types and reported to be most concentrated in mammalian platelets.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.1 mg bovine serum albumin

분석 메모

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)