추천 제품
형태
solid
색상
off-white
solubility
DMSO: 11 mg/mL
ethanol: 2.7 mg/mL
H2O: 3 mg/mL
SMILES string
OC(=O)\C=C/C(O)=O.CC(C)Oc1cccnc1N(C)C2CCN(CC2)Cc3ccccc3
InChI
1S/C21H29N3O.C4H4O4/c1-17(2)25-20-10-7-13-22-21(20)23(3)19-11-14-24(15-12-19)16-18-8-5-4-6-9-18;5-3(6)1-2-4(7)8/h4-10,13,17,19H,11-12,14-16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
KPYPLDPMBWPEBO-BTJKTKAUSA-N
유전자 정보
human ... DRD4(1815)
생화학적/생리학적 작용
U-101958 maleate salt is a selective D4 dopamine receptor antagonist. Studies have reported that U-101958 maleate cannot inhibit bromocriptine-mediated [3H]thymidine incorporation in opossum kidney (OK) cells.
제조 메모
U-101958 maleate salt is soluble in water (at 3 mg/mL), ethanol (2.7 mg/mL), and DMSO (11 mg/mL).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Substituted aminopiperidines as selective and potent D4-dopamine receptor antagonists.
Schlachter, S.K.
Abstr. Soc. Neurosci, 21, 253-253 (1995)
V A Narkar et al.
Journal of the American Society of Nephrology : JASN, 12(9), 1844-1852 (2001-08-24)
This study was conducted to determine the expression of dopamine D(2)-like receptors in opossum kidney (OK) cells and to examine the potential role of these receptors in mitogenesis. First, the presence of D(2)-like receptor binding sites in OK cell membranes
S K Schlachter et al.
European journal of pharmacology, 322(2-3), 283-286 (1997-03-19)
We have discovered two substituted 4-aminopiperidine compounds having high in vitro affinity and selectivity for the human dopamine D1 receptor. Both compounds, 3-ethoxy-N-methyl-N-[1-(phenylmethyl)-4-piperidinyl]-2-pyridinylamine (U-99363E), and its 3-isopropoxy analog (U-101958), were found through a routine receptor binding screen. The determined affinities
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