기술
HPLC: suitable
검사 파라미터
column: Kromasil 5-AmyCoat, 25 cm x 4.6 mm, 5 μm particles (K08670348)
mobile phase: 84:16 hexane: ethanol with 0.1% TFA
flow rate: 1 mL/min
pressure: 1117 psi (77 bar)
column temp.: 25 °C
detector: UV, 254 nm
injection: 20 μL
sample: 50 μg/mL atorva
적합성
application for HPLC
응용 분야
pharmaceutical (small molecule)
분석 메모
Atorvastatin calcium also known as HMG-CoA reductase inhibitors in a class of lipid-lowering medications that reduces levels of “bad” cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood and raise “good” cholesterol (high-density lipoprotein, or HDL). The enantiomer of atorvastatin (related compound E) could qualitatively and quantitatively differ in their activities, in pharmacokinetic behavior or pharmacodynamics. The application exhibits baseline resolution under 9 minutes of a racemic mixture of atorvastatin calcium and related compound E on a 5.0 μm Kromasil 5-AmyCoat Chiral.
법적 정보
Kromasil is a registered trademark of EKA Chemicals AB
분석물
설명
Atorvastatin related compound E (PHR1872)
Atorvastatin Calcium, Pharmaceutical Secondary Standard; Certified Reference Material
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