콘텐츠로 건너뛰기
Merck
모든 사진(1)

주요 문서

1148090

USP

Collagenase II

United States Pharmacopeia (USP) Reference Standard

동의어(들):

Collagenase from Clostridium histolyticum, Clostridiopeptidase A

로그인조직 및 계약 가격 보기


About This Item

CAS Number:
효소 위원회 번호:
MDL number:
UNSPSC 코드:
41116107
NACRES:
NA.24

Grade

pharmaceutical primary standard

제조업체/상표

USP

응용 분야

pharmaceutical

형식

neat

저장 온도

−70°C

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

Collagenase II is a metalloprotease that acts as an endoprotease and exhibits a tripeptidyl carboxypeptidase activity. It shows endopeptidic activity with the main cleavage site found in front of the human collagen duplex amino acids glycine-proline. Hydrolysis takes place in the interior of the triple helical domains of collagen. Collagenase II is also known as class II collagenase and consists of three subtypes: δ, ε, and ζ. Collagenase II USP reference standard is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

생화학적/생리학적 작용

Collagenase is activated by four gram atom calcium per mole enzyme. It is inhibited by ethylene glycol-bis(beta-aminoethyl ether) - N, N, N′,N′-tetraacetic acid, beta-mercaptoethanol, glutathione, thioglycolic acid and 8-hydroxyquinoline.

단위 정의

One collagen digestion unit (CDU) liberates peptides from collagen from bovine achilles tendon equivalent in ninhydrin color to 1.0 μmole of leucine in 5 hours at pH 7.4 at 37 °C in the presence of calcium ions. One FALGPA hydrolysis unit hydrolyzes 1.0 μmole of furylacryloyl-Leu-Gly-Pro-Ala per min at 25°C. One Neutral Protease unit hydrolyzes casein to produce color equivalent to 1.0 μmole of tyrosine per 5 hr at pH 7.5 at 37°C. One Clostripain Unit hydrolyzes 1.0 μmole of BAEE per min at pH 7.6 at 25°C in the presence of DTT.

분석 메모

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

기타 정보

This product is part of the USP Biologics program.

픽토그램

Health hazard

신호어

Danger

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Resp. Sens. 1

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our 문서 section.

도움이 필요하시면 연락하세요. 고객 지원 부서

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Xiaoya Chu et al.
Frontiers in endocrinology, 14, 1195618-1195618 (2023-06-22)
Testicular Leydig cells (LCs) are the primary known source of testosterone, which is necessary for maintaining spermatogenesis and male fertility. However, the isolation, identification, and functional analysis of testosterone in duck LCs are still ambiguous. The aim of the present
Anna Piaszyk-Borychowska et al.
Frontiers in immunology, 10, 1253-1253 (2019-06-25)
Atherosclerosis is a chronic inflammatory disease of the blood vessels, characterized by atherosclerotic lesion formation. Vascular Smooth Muscle Cells (VSMC), macrophages (MΦ), and dendritic cells (DC) play a crucial role in vascular inflammation and atherosclerosis. Interferon (IFN)α, IFNγ, and Toll-like
Yasin Emre Kaya et al.
Turkish neurosurgery, 30(3), 434-441 (2020-04-03)
To investigate the effects of metformin, a drug used widely for the treatment of type 2 diabetes mellitus, on human primary cell cultures prepared from uninjured segment of disc material intervertebral disk tissues. Primary cell cultures were prepared using the
?89.2? COLLAGENASE II
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 48(1), 6529-6529 (2022)
Dong Sun et al.
Iranian journal of basic medical sciences, 24(2), 150-159 (2021-05-07)
Physical exercise has emerged as an effective therapy to mitigate cardiac remodelling in diabetic cardiomyopathy (DCM). The results of our previous studies revealed mammalian sterile 20-like kinase 1 (Mst1) is a key regulator of the progression of DCM. However, the

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.