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  • Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Organic letters (2005-05-07)
Benedek Vakulya, Szilárd Varga, Antal Csámpai, Tibor Soós
초록

Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.

MATERIALS
제품 번호
브랜드
제품 설명

Sigma-Aldrich
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-10,11-dihydro-6′-methoxy-9-cinchonanyl]thiourea, 90%
Sigma-Aldrich
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-6′-methoxy-9-cinchonanyl]thiourea, 90%
Sigma-Aldrich
Nitromethane, ReagentPlus®, ≥99.0%
Sigma-Aldrich
Nitromethane, suitable for HPLC, ≥96%
Sigma-Aldrich
Nitromethane, ACS reagent, ≥95%