MilliporeSigma

CASP4

caspase 4, apoptosis-related cysteine peptidase

Synonyms:
ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Species:
UniProtKB ID:
Gene ID:
  • Human(837) Summary: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
  • Mouse(12363) caspase 4, apoptosis-related cysteine peptidase
  • Rat(114555) caspase 4, apoptosis-related cysteine peptidase
  • dog(403724) caspase 4, apoptosis-related cysteine peptidase
  • naked mole-rat(101700797) caspase 4, apoptosis-related cysteine peptidase
  • domestic guinea pig(100731032) caspase 4, apoptosis-related cysteine peptidase
  • cow(338039) caspase 4, apoptosis-related cysteine peptidase

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Caspase-4 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-CASP4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Monoclonal Anti-Caspase 11 antibody produced in rat, clone 17D9, purified from hybridoma cell culture,
Species Reactivity
mouse
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-Caspase-4, clone 17D9 Antibody, clone 17D9, from rat,
Species Reactivity
human, mouse
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-Caspase-13 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot

Proteins

Product Number
Description
Species
Caspase 4 human, recombinant, expressed in E. coli, 5,000 units/mg protein,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Casp4,
Species
mouse
MISSION® esiRNA, targeting human CASP4,
Species
human

Small Molecule - Substrate

Product Number
Description
Species
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin, ≥95% (HPLC), powder,
Species
rat, mouse, human