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C1354

Sigma-Aldrich

Monoclonal Anti-Caspase 11 antibody produced in rat

clone 17D9, purified from hybridoma cell culture

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Synonym(s):
Anti-CASP1
MDL number:
NACRES:
NA.41

biological source

rat

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

17D9, monoclonal

form

buffered aqueous solution

species reactivity

mouse

packaging

antibody small pack of 25 μL

concentration

~1 mg/mL

technique(s)

immunoblotting: 5-10 μg/mL using mouse EL4 cell extracts.
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable

isotype

IgG2a

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Casp4(12363)

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This Item
C4356C7729SAB4200693
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

antibody form

purified immunoglobulin

antibody form

purified from hybridoma cell culture

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

clone

17D9, monoclonal

clone

CAS9, monoclonal

clone

polyclonal

clone

11-5B, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

mouse

species reactivity

human

species reactivity

human, rat

species reactivity

pig (pig origin but not guinea pig), sheep, rat, bovine, rabbit, canine, human, mouse

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General description

Caspases are proteases having similar structure, substrate specificity and can be divided into three subfamilies based upon their amino acid sequence homology.Monoclonal Anti-Caspase 11 (rat IgG2a isotype) is derived from the 17D9 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a recombinant p30 subunit of mouse caspase 11. Caspase 11 (also known as Ich-3) gene encodes two protein products of 38 and 43 kDa that belong to the Ced3/ICE family of cystein proteases. Caspase 11 is an “upstream” caspase with a long prodomain. Caspase 11 is identified in murine and shares homology with the human caspase 4 and 5.

Immunogen

recombinant p30 subunit of mouse caspase 11.

Application

Monoclonal Anti-Caspase 11 antibody can be used in immunohistochemistry and immunoprecipitation. It is also useful in immunoblotting

Biochem/physiol Actions

Caspases are normally produced in the cell as inactive procaspases. Caspase 11 can induce apoptosis in cultured cells due to overexpression. Monoclonal antibodies reacting specifically with caspase 11 are useful tool for the study of the protease network, involved in development and regulation, governing the life and death of cells and tissues.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Arwa Abu Khweek et al.
Cellular immunology, 370, 104425-104425 (2021-11-21)
Asthma is an inflammatory lung disorder characterized by mucus hypersecretion, cellular infiltration, and bronchial hyper-responsiveness. House dust mites (HDM) are the most prevalent cause of allergic sensitization. Canonical and noncanonical inflammasomes are multiprotein complexes that assemble in response to pathogen
Caspase-11: the driving factor for noncanonical inflammasomes
Vigano E and Mortellaro A
European Journal of Immunology, 43(9), 2240-2245 (2013)
Chuang Yuan et al.
Cell death & disease, 13(8), 722-722 (2022-08-19)
Sepsis is a life-threatening syndrome with disturbed host responses to severe infections, accounting for the majority of death in hospitalized patients. However, effective medicines are currently scant in clinics due to the poor understanding of the exact underlying mechanism. We
Qi Zhou et al.
Frontiers in bioengineering and biotechnology, 10, 823933-823933 (2022-03-31)
The communication between macrophages and tendon cells plays a critical role in regulating the tendon-healing process. However, the potential mechanisms through which macrophages can control peritendinous fibrosis are unknown. Our data showed a strong pro-inflammatory phenotype of macrophages after a
Caspase functions in cell death and disease
McIlwain DR, et al.
Cold Spring Harbor Perspectives in Biology, 5(4), a008656-a008656 (2013)

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