MilliporeSigma

CDC42

cell division cycle 42

Synonyms:
CDC42Hs, G25K
Species:
UniProtKB ID:
Gene ID:
  • Human(998) Summary: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
  • Mouse(12540) cell division cycle 42
  • Rat(64465) cell division cycle 42 (GTP binding protein)
  • sheep(101102792) cell division cycle 42 (GTP binding protein, 25kDa)
  • dog(403934) cell division cycle 42 (GTP binding protein, 25kDa)
  • fruit fly(32981) CG12530 gene product from transcript CG12530-RC
  • Zebrafish(336839) cell division cycle 42
  • chicken(395917) cell division cycle 42 (GTP binding protein, 25kDa)
  • domestic guinea pig(100717195) cell division cycle 42
  • naked mole-rat(101701374) cell division cycle 42
  • domestic cat(101094772) cell division cycle 42 (GTP binding protein, 25kDa)
  • cow(532712) cell division cycle 42 (GTP binding protein, 25kDa)

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Cdc42 Antibody, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Cdc42 Antibody, clone 2D16 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, canine, feline, human, monkey, mouse, porcine, rat, zebrafish
Application
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-CDC42 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
dog, human, rabbit
Application
immunohistochemistry
western blot
Anti-CDC42 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-CDC42 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot

Kits

Product Number
Description
Species
Cdc42 Activation Assay Kit, Non-radioactive cdc42 Activation Assay Kit can be used to precipitate cdc42-GTP from cell lysates subjected to various treatments & detection by a cdc42 specific monoclonal antibody.,
Species
human
Rac/cdc42 Assay Reagent (PAK1 PBD, agarose), 300 µg, Specifically binds to & precipitates Rac-GTP & cdc42-GTP from cell lysates. For use in Affinity Binding Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CDC42,
Species
human
MISSION® esiRNA, targeting mouse Cdc42,
Species
mouse