MilliporeSigma

CNR1

cannabinoid receptor 1 (brain)

Synonyms:
CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR
Species:
UniProtKB ID:
Gene ID:
  • Human(1268) Summary: This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
  • Mouse(12801) cannabinoid receptor 1 (brain)
  • Rat(25248) cannabinoid receptor 1 (brain)
  • Zebrafish(404209) cannabinoid receptor 1
  • Horse(100065681) cannabinoid receptor 1 (brain)
  • naked mole-rat(101697935) cannabinoid receptor 1 (brain)
  • domestic guinea pig(100169690) cannabinoid receptor 1 (brain)
  • cow(100299449) cannabinoid receptor 1 (brain)
  • sheep(101111639) cannabinoid receptor 1 (brain)
  • domestic cat(493926) cannabinoid receptor 1 (brain)
  • dog(481913) cannabinoid receptor 1 (brain)
  • chicken(428633) cannabinoid receptor 1 (brain)

Custom & Knockdown Gene Products

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Small Molecule - Agonist

Product Number
Description
Species
Delta-9-Tetrahydrocannabinol, United States Pharmacopeia (USP) Reference Standard,
Species
human
Arachidonylethanolamide, ≥97.0% (TLC), oil,
Species
rat
(R)-(+)-WIN 55,212-2 mesylate salt, ≥98% (HPLC),
Species
human
Arachidonyl-2′-chloroethylamide hydrate, ≥97% (HPLC), oil,
Species
rat, mouse
Δ9-Tetrahydrocannabinol solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis,
Species
human, mouse, rat

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Cannabidiol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Cannabidiol solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis,
Species
human, rat

Small Molecule - Antagonist

Product Number
Description
Species
AM281, ≥98% (HPLC),
Species
rat
Rimonabant hydrochloride, ≥98% (HPLC),
Species
human
Stearoyl ethanolamide, ≥98%, crystalline,
Species
rat
L-Thyroxine sodium salt pentahydrate, ≥98% (HPLC), powder,
Species
mouse, rat
L-Thyroxine sodium salt pentahydrate, γ-irradiated, powder, BioXtra, suitable for cell culture,
Species
mouse, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CNR1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-Cannabinoid receptor 1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
rat
Application
ELISA
western blot
Anti-CNR1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, canine, human, mouse, pig, rat
Application
ELISA
western blot
Monoclonal Anti-CNR1, (N-terminal) antibody produced in mouse, clone 1F9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-CNR1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
JWH-015, ≥98% (HPLC), powder,
Species
rat, human
Palmitoylethanolamide, ,
Species
human, rat
CP-55940, >98% (HPLC), powder,
Species
human, rat
Δ9-Tetrahydrocannabinol solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis,
Species
human, mouse, rat
Δ9-Tetrahydrocannabinol solution, ethanol solution,
Species
human, mouse, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Cnr1,
Species
mouse
MISSION® esiRNA, targeting human CNR1,
Species
human