MilliporeSigma

EGFR

epidermal growth factor receptor

Synonyms:
ERBB, ERBB1, HER1, PIG61, mENA
Species:
UniProtKB ID:
Gene ID:
  • Human(1956) Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(13649) epidermal growth factor receptor
  • Rat(24329) epidermal growth factor receptor
  • sheep(780479) epidermal growth factor receptor
  • domestic guinea pig(100725363) epidermal growth factor receptor
  • dog(404306) epidermal growth factor receptor
  • fruit fly(37455) Epidermal growth factor receptor
  • Horse(100067755) epidermal growth factor receptor
  • cow(407217) epidermal growth factor receptor
  • naked mole-rat(101723771) epidermal growth factor receptor
  • domestic cat(100510799) epidermal growth factor receptor
  • chicken(396494) epidermal growth factor receptor

Custom & Knockdown Gene Products

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ELISA

Product Number
Description
Species
Phosphotyrosine EGFR / Epidermal Growth Factor Receptor ELISA Kit, ,
Species
human
Cell-Based ELISA for detecting phospho-EGFR (pTyr992) in cultured cell lines, 96 assays,
Species
human
Cell-Based ELISA for detecting phospho-EGFR (pTyr1068) in cultured cell lines, 96 assays,
Species
human
Cell-Based ELISA for detecting phospho-EGFR, in cultured cell lines, 96 assays,
Species
human
Cell-Based phospho-EGFR ELISA Sampler Kit, for detecting phospho-egfr(pTyr845), phospho-egfr(pTyr992), phospho-egfr(pTyr1068) and phospho-egfr in cultured cell lines,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Tyrphostin AG 1478, ≥98%,
Species
human, mouse
SU 5416, ≥98% (HPLC),
Species
human, mouse
Genistein, from Glycine max (soybean), ~98% (HPLC),
Species
mouse, human, rat
Genistein, synthetic, ≥98% (HPLC), powder,
Species
mouse, human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-EGFR antibody produced in mouse, clone 4H2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal, clone C-273, purified from hybridoma cell culture,
Species Reactivity
drosophila
Application
ELISA
immunohistochemistry

western blot
Anti-phospho-Epidermal Growth Factor Receptor (pTyr1068) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, rat
Application
western blot
Anti-Epidermal Growth Factor Receptor antibody produced in goat, affinity isolated antibody, lyophilized powder,
Species Reactivity
mouse
Application
immunohistochemistry
western blot
Anti-phospho-EGFR (pTyr1197) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
DAPH, ≥98% (HPLC), solid,
Species
human
Gefitinib for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Erlotinib hydrochloride, ,
Species
human
Tyrphostin 1, ≥98%,
Species
human
Gefitinib, European Pharmacopoeia (EP) Reference Standard,
Species
human

Proteins

Product Number
Description
Species
EGFR (695-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
EGF-receptor human, recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Species
human
Epidermal Growth Factor Receptor human, buffered aqueous glycerol solution, 5,000-30,000 units/mg protein (Lowry),
Species
human
Epidermal Growth Factor Receptor human, lyophilized powder, ≥15,000 units/mg protein (Bradford),
Species
human
EGFR (D746-750 T790M C797S), Active, PRECISIO® Kinase, recombinant,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Egfr,
Species
mouse
MISSION® esiRNA, targeting human EGFR,
Species
human