MilliporeSigma

GRM1

glutamate receptor, metabotropic 1

Synonyms:
GPRC1A, MGLU1, MGLUR1, SCAR13
Species:
UniProtKB ID:
Gene ID:
  • Human(2911) Summary: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
  • Mouse(14816) glutamate receptor, metabotropic 1
  • Rat(24414) glutamate receptor, metabotropic 1
  • domestic guinea pig(100730891) glutamate receptor, metabotropic 1
  • naked mole-rat(101712477) glutamate receptor, metabotropic 1
  • Zebrafish(100150246) glutamate receptor, metabotropic 1
  • chicken(421614) glutamate receptor, metabotropic 1
  • dog(484024) glutamate receptor, metabotropic 1
  • Horse(100060603) glutamate receptor, metabotropic 1
  • domestic cat(101094104) glutamate receptor, metabotropic 1
  • cow(540485) glutamate receptor, metabotropic 1
  • Domestic Rabbit(100356201) glutamate receptor, metabotropic 1

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Small Molecule - Agonist

Product Number
Description
Species
(S)-3,5-Dihydroxyphenylglycine hydrate, ≥98% (HPLC), powder,
Species
human
Ibotenic acid, ~95%, solid,
Species
rat
D-2-Aminoadipic acid, ,
Species
rat
L-2-Aminoadipic acid, ≥98% (TLC),
Species
rat, human
Quisqualic acid, powder,
Species
rat

Small Molecule - Antagonist

Product Number
Description
Species
(+)-α-Methyl-4-carboxyphenylglycine, solid,
Species
rat
AIDA, solid,
Species
rat, human
SIB 1893, >99%, solid,
Species
human
SIB 1757, ≥99% (HPLC), crystalline,
Species
human
D-2-Aminoadipic acid, ,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GRM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-mGluR1 Antibody, Upstate®, from rabbit,
Species Reactivity
rat
Application
western blot
Monoclonal Anti-Glutamate antibody produced in mouse, clone GLU-4, ascites fluid,
Species Reactivity
wide range
Application
ELISA
Anti-Metabotropic Glutamate Receptor 1 Antibody, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-GRM1 antibody produced in mouse, clone 1F7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
L-2-Aminoadipic acid, ≥98% (TLC),
Species
rat, human
Quisqualic acid, powder,
Species
rat
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
(Aminomethyl)phosphonic acid, 99%,
Species
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
(±)-AMPA, solid,
Species
rat
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GRM1,
Species
human
MISSION® esiRNA, targeting mouse Grm1,
Species
mouse