MilliporeSigma

GRM2

glutamate receptor, metabotropic 2

Synonyms:
GLUR2, GPRC1B, MGLUR2, mGlu2
Species:
UniProtKB ID:
Gene ID:
  • Human(2912) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(108068) glutamate receptor, metabotropic 2
  • Rat(24415) glutamate receptor, metabotropic 2
  • domestic guinea pig(100720736) glutamate receptor, metabotropic 2
  • naked mole-rat(101722804) glutamate receptor, metabotropic 2
  • chicken(427575) glutamate receptor, metabotropic 2
  • dog(484751) glutamate receptor, metabotropic 2
  • Horse(100052178) glutamate receptor, metabotropic 2
  • domestic cat(101098611) glutamate receptor, metabotropic 2
  • cow(519904) glutamate receptor, metabotropic 2
  • sheep(101116870) glutamate receptor, metabotropic 2

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Agonist

Product Number
Description
Species
Ibotenic acid, ~95%, solid,
Species
rat
D-2-Aminoadipic acid, ,
Species
rat
L-2-Aminoadipic acid, ≥98% (TLC),
Species
rat, human
Quisqualic acid, powder,
Species
rat
trans-(±)-ACPD monohydrate, solid, ≥97% (NMR),
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
D-2-Aminoadipic acid, ,
Species
rat
Quisqualic acid, powder,
Species
rat
DL-2-Amino-3-phosphonopropionic acid, ,
Species
human
(±)-AMPA, solid,
Species
rat
(Aminomethyl)phosphonic acid, 99%,
Species
rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GRM2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry
Anti-GRM2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
Anti-GRM2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, canine, human, mouse, pig, rat
Application
ELISA
immunohistochemistry

western blot
Anti-GRM2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-Metabotropic Glutamate Receptor 2 Antibody, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
L-2-Aminoadipic acid, ≥98% (TLC),
Species
rat, human
Quisqualic acid, powder,
Species
rat
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
(Aminomethyl)phosphonic acid, 99%,
Species
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human

Small Molecule - Ligand

Product Number
Description
Species
Quisqualic acid, powder,
Species
rat

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
(±)-AMPA, solid,
Species
rat
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Grm2,
Species
mouse