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MAPK10

mitogen-activated protein kinase 10

Synonyms:
JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK
Species:
UniProtKB ID:
Gene ID:
  • Human(5602) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Mouse(26414) mitogen-activated protein kinase 10
  • Rat(25272) mitogen activated protein kinase 10
  • Horse(100052608) mitogen-activated protein kinase 10
  • Domestic Rabbit(100337999) mitogen-activated protein kinase 10
  • domestic guinea pig(100718766) mitogen-activated protein kinase 10
  • Zebrafish(569698) mitogen-activated protein kinase 10
  • sheep(101120665) mitogen-activated protein kinase 10
  • dog(478464) mitogen-activated protein kinase 10
  • domestic cat(101101463) mitogen-activated protein kinase 10
  • naked mole-rat(101712980) mitogen-activated protein kinase 10
  • cow(537631) mitogen-activated protein kinase 10
  • chicken(422592) mitogen-activated protein kinase 10

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Antibodies

Product Number
Description
Species Reactivity
Application
ANTI-MAPK10 antibody produced in mouse, clone 3A3-1A8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-JNK3 Antibody, clone 2O10P2, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
Anti-MAPK10 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Monoclonal Anti-MAPK10 antibody produced in mouse, clone 3B9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-JNK3/SAPK1b Antibody, clone C05T, rabbit monoclonal, culture supernatant, clone C05T, from rabbit,
Species Reactivity
human, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
SP600125, ≥98% (HPLC),
Species
human
Adenine, BioReagent, suitable for plant cell culture, ≥99%,
Species
human, rat, mouse
Adenine, ≥99%,
Species
human, rat, mouse
Adenine, BioReagent, suitable for cell culture,
Species
human, rat, mouse

Proteins

Product Number
Description
Species
JNK3/SAPK1b Protein, active, 10 µg, Active, N-terminal His6 tagged, recombinant, full length human JNK3/SAPK1b, for use in Kinase Assays.,
Species
human
JNK3/SAPK1b Protein, inactive, 50 g, Unactive, N-terminal His6-tagged recombinant human JNK3/SAPK1b, for use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human MAPK10,
Species
human