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MECP2

methyl CpG binding protein 2 (Rett syndrome)

Synonyms:
AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT
Species:
UniProtKB ID:
Gene ID:
  • Human(4204) Summary: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq, Jul 2009]
  • Mouse(17257) methyl CpG binding protein 2
  • Rat(29386) methyl CpG binding protein 2
  • domestic cat(101082385) methyl CpG binding protein 2 (Rett syndrome)
  • Zebrafish(335250) methyl CpG binding protein 2
  • Domestic Rabbit(100328751) methyl CpG binding protein 2 (Rett syndrome)
  • dog(612973) methyl CpG binding protein 2 (Rett syndrome)
  • domestic guinea pig(100734864) methyl CpG binding protein 2 (Rett syndrome)
  • sheep(101121154) methyl CpG binding protein 2 (Rett syndrome)
  • naked mole-rat(101700584) methyl CpG binding protein 2 (Rett syndrome)
  • cow(539629) methyl CpG binding protein 2 (Rett syndrome)

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-MECP2 antibody produced in rabbit, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-MECP2 antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Monoclonal Anti-MECP2 antibody produced in mouse, clone 4B6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
mouse
Application
ELISA
immunohistochemistry

western blot
Monoclonal Anti-MECP2 antibody produced in mouse, clone 1B11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry

western blot
Anti-MeCP2 Antibody, clone 4H7, clone 4H7, from rat,
Species Reactivity
mouse, porcine, rat
Application
ChIP
immunocytochemistry

immunohistochemistry

immunoprecipitation (IP)

western blot

Proteins

Product Number
Description
Species
MECP2 human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Mecp2,
Species
mouse
MISSION® esiRNA, targeting human MECP2,
Species
human