MilliporeSigma

POLG

polymerase (DNA directed), gamma

Synonyms:
MDP1, MIRAS, MTDPS4A, MTDPS4B, PEO, POLG1, POLGA, SANDO, SCAE
Species:
UniProtKB ID:
Gene ID:
  • Human(5428) Summary: Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(18975) polymerase (DNA directed), gamma
  • Rat(85472) polymerase (DNA directed), gamma
  • Zebrafish(100150924) polymerase (DNA directed), gamma
  • Horse(100053827) polymerase (DNA directed), gamma
  • dog(488732) polymerase (DNA directed), gamma
  • naked mole-rat(101700433) polymerase (DNA directed), gamma
  • domestic cat(101083771) polymerase (DNA directed), gamma
  • cow(533090) polymerase (DNA directed), gamma
  • chicken(404292) polymerase (DNA directed), gamma
  • sheep(101123414) polymerase (DNA directed), gamma
  • domestic guinea pig(100728907) polymerase (DNA directed), gamma

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-DNA polymerase subunit gamma-1 Antibody/POLG, 1.0 mg/mL, from rabbit,
Species Reactivity
human
Application
immunohistochemistry
immunoprecipitation (IP)
Anti-DNA Polymerase gamma Antibody, clone 9V9D9, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
Anti-POLG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-POLG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
Aphidicolin from Nigrospora sphaerica, ≥98% (HPLC), powder,
Species
human
Sodium phosphonoformate tribasic hexahydrate, ,
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human POLG,
Species
human
MISSION® esiRNA, targeting mouse Polg,
Species
mouse