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A0781

Sigma-Aldrich

Aphidicolin from Nigrospora sphaerica

≥98% (HPLC), powder

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Synonym(s):
APC
Empirical Formula (Hill Notation):
C20H34O4
CAS Number:
Molecular Weight:
338.48
Beilstein:
4689958
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

optical activity

[α]27/D +12°, c = 1 in methanol(lit.)

color

white

mp

227-233 °C (lit.)

solubility

ethanol: 1 mg/mL (stable at least a week at 4°C.)
DMSO: 10 mg/mL (stable at least six weeks at −20°C.)
methanol: 10 mg/mL
H2O: insoluble

antibiotic activity spectrum

neoplastics
viruses

Mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

[H][C@@]12CC[C@@]3([H])[C@](C)(CO)[C@H](O)CC[C@]3(C)[C@]14CC[C@](O)(CO)[C@]([H])(C2)C4

InChI

1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

InChI key

NOFOAYPPHIUXJR-APNQCZIXSA-N

Gene Information

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This Item
SML0075SML0230C002
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Sigma-Aldrich

SML0075

OBAA

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SML0230

GW-803430

form

powder

form

powder

form

powder

form

powder

color

white

color

white to tan

color

white to beige

color

white

solubility

ethanol: 1 mg/mL (stable at least a week at 4°C.), DMSO: 10 mg/mL (stable at least six weeks at −20°C.), methanol: 10 mg/mL, H2O: insoluble

solubility

DMSO: ≥5 mg/mL at 60 °C

solubility

DMSO: ≥4 mg/mL at warmed to 60 °C

solubility

chloroform: soluble (but decomposes within 24 hrs), methanol: stable (for up to two weeks at -20°C.)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

300

Quality Level

-

Quality Level

100

Quality Level

-

Biochem/physiol Actions

Aphidicolin is an antibiotic, a potent antiviral and antimitotic agent and DNA polymerase inhibitor.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Caution

Estimated shelf-life is two years. For optimal stability, it should be protected from light and stored desiccated.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Articles

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.

n proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during the synthesis (S) phase, which is followed by a second gap phase (G2) during which growth and preparation for cell division occurs. Together, these three stages comprise the interphase phase of the cell cycle. Interphase is followed by the mitotic (M) phase.

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