MilliporeSigma

PPM1D

protein phosphatase, Mg2+/Mn2+ dependent, 1D

Synonyms:
PP2C-DELTA, WIP1
Species:
UniProtKB ID:
Gene ID:
  • Human(8493) Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
  • Mouse(53892) protein phosphatase 1D magnesium-dependent, delta isoform
  • Rat(287585) protein phosphatase, Mg2+/Mn2+ dependent, 1D
  • domestic cat(101089556) protein phosphatase, Mg2+/Mn2+ dependent, 1D
  • chicken(417644) protein phosphatase, Mg2+/Mn2+ dependent, 1D
  • Horse(100071325) protein phosphatase, Mg2+/Mn2+ dependent, 1D
  • naked mole-rat(101698863) protein phosphatase, Mg2+/Mn2+ dependent, 1D
  • dog(612934) protein phosphatase, Mg2+/Mn2+ dependent, 1D
  • domestic guinea pig(100731559) protein phosphatase, Mg2+/Mn2+ dependent, 1D
  • cow(514005) protein phosphatase, Mg2+/Mn2+ dependent, 1D
  • sheep(101108932) protein phosphatase, Mg2+/Mn2+ dependent, 1D

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Antibodies

Product Number
Description
Species Reactivity
Application
ANTI-PPM1D (CENTER) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-PPM1D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-PPM1D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Monoclonal Anti-PPM1D antibody produced in mouse, clone 4D1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Ppm1d,
Species
mouse
MISSION® esiRNA, targeting human PPM1D,
Species
human