MilliporeSigma

TUBA1A

tubulin, alpha 1a

Synonyms:
B-ALPHA-1, LIS3, TUBA3
Species:
UniProtKB ID:
Gene ID:
  • Human(7846) Summary: Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
  • Mouse(22142) tubulin, alpha 1A
  • Rat(64158) tubulin, alpha 1A
  • Horse(100051840) tubulin, alpha 1a
  • cow(404053) tubulin, alpha 1a
  • domestic cat(101096902) tubulin, alpha 1a
  • dog(608147) tubulin, alpha 1a
  • domestic guinea pig(100726777) tubulin, alpha 1a

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ALPHA-TUBULIN antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-TUBA1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-TUBA1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-alpha-Tubulin Antibody, clone RM113, clone RM113, from rabbit,
Species Reactivity
human
Application
immunocytochemistry
western blot
Anti-alpha-Tubulin antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM113, purified immunoglobulin,
Species Reactivity
all
Application
ChIP
ELISA

flow cytometry

immunocytochemistry

immunohistochemistry

immunoprecipitation (IP)

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Docetaxel, purum, ≥97.0% (HPLC),
Species
human
Anhydrous Docetaxel, European Pharmacopoeia (EP) Reference Standard,
Species
human
Vinblastine sulfate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Vinblastine sulfate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Colchicine, (European Pharmacopoeia (EP) Reference Standard),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Tuba1a,
Species
mouse
MISSION® esiRNA, targeting human TUBA1A,
Species
human