Intensified and Continuous Downstream Processing

Gain operational efficiency and flexibility while reducing footprint and costs

Looking to increase your downstream process efficiency?

Transformation of the biomanufacturing workflow is being accelerated by the demand for new therapeutics combined with the need to reduce costs while ensuring operational flexibility and productivity.

Process intensification, closed, and continuous bioprocessing are foundational strategies for achieving these goals. They are widely and successfully deployed in the downstream suite to be more efficient, faster, smaller, less expensive, and sustainable.

To help biopharmaceutical manufacturers intensify, closing, digitally-enhance, or go fully continuous with their processes and gain new levels of operational efficiency and flexibility, there are multiple levers within the DSP suite.


Use of single-pass tangential flow filtration (SPTFF) eliminates the need for hold tanks or a retentate loop, allowing flow-through operation and intensified downstream processing of monoclonal antibodies. Productivity and efficiency of the mAb DSP workflow can be further increased by coupling SPTFF with chromatography unit operations. SPTFF is also uniquely positioned to enable high-concentration formulations with improved product recovery during the final formulation step.

  •  Pellicon® SPTFF offers an unparalleled solution to reduce in-process volumes within downstream processing of drug products, reach concentrations and yields unachievable with batch TFF due to working volume limits, and enable connected and continuous processes.
  • Pellicon® Cassettes consistently and reliably deliver purity assurance at every stage and scale throughout the life of a drug product.
  • Pellicon® Capsules for the filtration of feedstreams that require single-use capabilities, including enhanced ease-of-use, process flexibility, product turnaround, and reduced operator exposure.

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