Skip to Content
MilliporeSigma
All Photos(3)

Documents

140112

Sigma-Aldrich

4-Nitrobenzyl chloride

99%

Synonym(s):

α-Chloro-4-nitrotoluene

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
O2NC6H4CH2Cl
CAS Number:
Molecular Weight:
171.58
Beilstein/REAXYS Number:
387187
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

99%

form

solid

mp

70-73 °C (lit.)

solubility

chloroform: soluble 50 mg/mL, clear to very slightly hazy, faintly yellow

SMILES string

[O-][N+](=O)c1ccc(CCl)cc1

InChI

1S/C7H6ClNO2/c8-5-6-1-3-7(4-2-6)9(10)11/h1-4H,5H2

InChI key

KGCNHWXDPDPSBV-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

4-Nitrobenzyl chloride acts as substrate for glutathione S-transferase(GST) in determination of GST in Chinese fetal liver. It undergoes reduction by NADPH to yield 4-nitrotoluene.

Application

4-Nitrobenzyl chloride was used to prepare unsymmetrically N,N′-bis(substituted) 4,13-diaza-18-crown-6-ether derivatives.

pictograms

CorrosionExclamation mark

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Skin Corr. 1B

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 1

1 of 1

S N Moreno et al.
The Journal of biological chemistry, 261(17), 7811-7815 (1986-06-15)
The o-, m-, and p-nitrobenzyl chlorides are reduced aerobically and anaerobically by NADPH and rat hepatic microsomes. Under aerobic conditions, these nitro anion radicals reduce oxygen to superoxide as demonstrated by oxygen consumption and spin trapping of superoxide with 5,5-dimethyl-1-pyrroline
K Datta et al.
Early human development, 37(3), 167-174 (1994-06-01)
Glutathione S-transferase (GST) with activity towards CDNB as a substrate from human intrauterine conceptual tissues (HICT) at 6-10 weeks of gestation was purified approximately 200-fold by GSH coupled Sepharose 4B affinity chromatography. The preparations of affinity purified HICT-GST were used
P Jemth et al.
Biochemistry, 38(31), 9982-9991 (1999-08-06)
The reaction mechanism of rat glutathione transferase T2-2 has been studied using pre-steady-state and steady-state kinetics. Several parts of the catalytic cycle including binding of substrates, product formation, and product release were investigated. Under saturating conditions, a two-step product release
Shingo Arakawa et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(3), 497-503 (2011-12-16)
We investigated the impact of glutathione transferases Mu 1 (GSTM1)- and glutathione transferase Theta 1 (GSTT1)-null genotypes on hepatic GST activities in humans and compared the results with those of Gstm1- and Gstt1-null mice. In liver with GSTM1/Gstm1-null genotype, GST
J J Jaffe et al.
Molecular and biochemical parasitology, 20(2), 199-206 (1986-08-01)
Glutathione S-transferase (EC 2.5.1.18) was detected in the cytosolic and microsomal fractions of adult Dirofilaria immitis females at respective levels of 30 nmol and 3 nmol min-1 (mg protein)-1 activity with the substrate 1-chloro-2,4-dinitrobenzene (CDNB). The transferase activity in the

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service