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142859

Sigma-Aldrich

Difluoroacetic acid

98%

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Synonym(s):
1,1-Difluoroacetic acid, 2,2-Difluoroacetic acid
Linear Formula:
F2CHCO2H
CAS Number:
Molecular Weight:
96.03
Beilstein:
1098588
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

98%

form

liquid

refractive index

n20/D 1.344 (lit.)

bp

132-134 °C (lit.)

mp

−1 °C (lit.)

density

1.526 g/mL at 25 °C (lit.)

SMILES string

OC(=O)C(F)F

InChI

1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)

InChI key

PBWZKZYHONABLN-UHFFFAOYSA-N

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This Item
T6508TX127591707
Difluoroacetic acid 98%

Sigma-Aldrich

142859

Difluoroacetic acid

Trifluoroacetic acid ReagentPlus®, 99%

Sigma-Aldrich

T6508

Trifluoroacetic acid

Trifluoroacetic acid Meets Reagent Specifications for testing USP/NF monographs

Supelco

TX1275

Trifluoroacetic acid

Trifluoroacetic acid puriss. p.a., suitable for HPLC, ≥99.0% (GC)

Sigma-Aldrich

91707

Trifluoroacetic acid

form

liquid

form

liquid

form

liquid

form

liquid

refractive index

n20/D 1.344 (lit.)

refractive index

n20/D 1.3 (lit.)

refractive index

n20/D 1.3 (lit.)

refractive index

n20/D 1.3 (lit.)

bp

132-134 °C (lit.)

bp

72.4 °C (lit.)

bp

72.4 °C (lit.)

bp

72.4 °C (lit.)

mp

−1 °C (lit.)

mp

−15.4 °C (lit.)

mp

−15.4 °C (lit.)

mp

−15.4 °C (lit.)

density

1.526 g/mL at 25 °C (lit.)

density

1.489 g/mL at 20 °C (lit.)

density

1.489 g/mL at 20 °C (lit.)

density

1.489 g/mL at 20 °C (lit.)

General description

Difluoroaceticacid is a monocarboxylic acid and an organofluorine compound. Difluoroaceticacid is easy-to-handle reagent, useful for obtaining difluoromethyl substituents. Difluoroacetic acid can be used asdifluoromethylating reagent for the direct C−H difluoromethylation ofheteroaromatic compounds.

Application

Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine.

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

172.4 °F - closed cup

Flash Point(C)

78 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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To facilitate mass transport and column efficiency, solutes must have free access to particle pores to facilitate interactions with the stationary phase. To ensure this feature, particles should be used for HPLC separations which have pores sufficiently large to accommodate
N Illy et al.
Comptes rendus des seances de la Societe de biologie et de ses filiales, 175(2), 242-246 (1981-01-01)
Our experiments were carried out in normal and streptozotocin-diabetic rats. The effects of sodium difluoroacetate (DFA) at the dose of 40 mg/kg daily were studied on the blood and retinal lactate levels; these effects were compared to those of an
Difluoroacetic acid as a new reagent for direct C- H difluoromethylation of heteroaromatic compounds
Tung TT, et al.
Chemistry?A European Journal , 23(72), 18125-18128 (2017)
The direct C--H difluoromethylation of heteroarenes based on the photolysis of hypervalent iodine (III) reagents that contain difluoroacetoxy ligands
Sakamoto R. et al.
Organic Letters, 19(19), 5126-5129 (2017)

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