MilliporeSigma
All Photos(1)

Documents

185892

Sigma-Aldrich

Ethyl chloroformate

97%

Sign Into View Organizational & Contract Pricing

Synonym(s):
Chloroformic acid ethyl ester
Linear Formula:
ClCOOC2H5
CAS Number:
Molecular Weight:
108.52
Beilstein:
385653
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

vapor density

3.74 (vs air)

Quality Level

vapor pressure

3.42 psi ( 20 °C)

Assay

97%

form

liquid

autoignition temp.

842 °F

refractive index

n20/D 1.395 (lit.)

bp

93 °C (lit.)

mp

−81 °C (lit.)

solubility

alcohol: miscible
benzene: miscible
chloroform: miscible
diethyl ether: miscible
water: insoluble

density

1.135 g/mL at 25 °C (lit.)

SMILES string

CCOC(Cl)=O

InChI

1S/C3H5ClO2/c1-2-6-3(4)5/h2H2,1H3

InChI key

RIFGWPKJUGCATF-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
1779891299012980
Ethyl chloroformate 97%

Sigma-Aldrich

185892

Ethyl chloroformate

Ethyl benzoylacetate technical, ≥95% (HPLC)

Sigma-Aldrich

12990

Ethyl benzoylacetate

Ethyl benzoylacetate redist., ≥97.0% (HPLC)

Sigma-Aldrich

12980

Ethyl benzoylacetate

form

liquid

form

liquid

form

liquid

form

-

refractive index

n20/D 1.395 (lit.)

refractive index

n20/D 1.407 (lit.)

refractive index

n20/D 1.52 (lit.), n20/D 1.520-1.540

refractive index

n20/D 1.52 (lit.), n20/D 1.531

bp

93 °C (lit.)

bp

128.8 °C (lit.)

bp

265-270 °C (lit.)

bp

265-270 °C (lit.)

mp

−81 °C (lit.)

mp

-

mp

-

mp

-

solubility

alcohol: miscible, benzene: miscible, chloroform: miscible, diethyl ether: miscible, water: insoluble

solubility

benzene: miscible, chloroform: miscible, diethyl ether: miscible

solubility

H2O: insoluble, alcohol: miscible, diethyl ether: miscible

solubility

H2O: insoluble, alcohol: miscible, diethyl ether: miscible

Application

  • Ethyl chloroformate was used in the synthesis of nitrile oxides.
  • It was used as derivatization reagent to investigate stereochemical conversion of chiral non-steroidal anti-inflammatory drugs during derivatization reaction.
  • It was used to develop flexible template strategy for the generation of nanometer-scale templates via dip-pen nanolithography.
  • It was used as derivatization reagent in an enantiomeric analysis of amino acids by two-dimensional gas chromatography.
  • It was also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles.

Packaging

Derivatization reagent employed in an enantiomeric analysis of amino acids by two-dimensional gas chromatography. Also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles.

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Met. Corr. 1 - Skin Corr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

60.8 °F

Flash Point(C)

16 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

M R Wright et al.
Journal of chromatography, 616(1), 59-65 (1993-06-23)
A potential problem with chiral derivatization is the possibility of stereochemical conversion during the derivatization reaction. This possibility has been examined using the non-steroidal anti-inflammatory drugs ibuprofen, ketoprofen, etodolac and flurbiprofen. To avoid possible interference from stereochemical impurities, male Sprague-Dawley
Sezin Erarpat et al.
Journal of separation science, 43(6), 1100-1106 (2019-12-21)
A green and fast analytical method for the determination of l-methionine in human plasma is presented in this study. Preconcentration of the analyte was carried out by switchable solvent liquid phase microextraction after ethyl chloroformate derivatization reaction. Instrumental detection of
A convenient preparative method of nitrile oxides by the dehydration of primary nitro compounds with ethyl chloroformate or benzenesulfonyl chloride in the presence of triethylamine.
Shimizu T, et al.
Bulletin of the Chemical Society of Japan, 59(9), 2827-2831 (1986)
Melanie Junge et al.
Chirality, 19(3), 228-234 (2007-01-19)
The chiral separation of amino acids (AA) derivatised with ethyl chloroformate by using comprehensive two-dimensional gas chromatography is reported. A commercially available enantioselective capillary column (Chirasil-l-Val) has been tested as first-dimension column. Two nonenantioselective stationary phases (BPX50 and BP1) with
Dip-Pen Nanolithography of Chemical Templates on Silicon Oxide.
Kooi SE, et al.
Advanced Materials, 16(12), 1013-1016 (2004)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service