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19240

Sigma-Aldrich

Butyramide

≥98.0% (T)

Synonym(s):

Amide C4

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About This Item

Linear Formula:
CH3CH2CH2CONH2
CAS Number:
Molecular Weight:
87.12
Beilstein/REAXYS Number:
1361528
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

assay

≥98.0% (T)

mp

114-116 °C

solubility

alcohol: soluble(lit.)
diethyl ether: slightly soluble(lit.)
water: soluble(lit.)

functional group

amide

SMILES string

CCCC(N)=O

InChI

1S/C4H9NO/c1-2-3-4(5)6/h2-3H2,1H3,(H2,5,6)

Inchi Key

DNSISZSEWVHGLH-UHFFFAOYSA-N

Gene Information

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Application

Butyramide was used in the synthesis of hydroxamic acids, electrorheological fluids and β-amodoorganotin compounds. It was used as substrate of (+)-γ-lactamase to develop a microreactor to study enzyme stability, activity, kinetics and substrate specificity.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Maja D Vitorović-Todorović et al.
Bioorganic & medicinal chemistry, 18(3), 1181-1193 (2010-01-12)
Synthesis and anticholinesterase activity of 4-aryl-4-oxo-N-phenyl-2-aminylbutyramides, novel class of reversible, moderately potent cholinesterase inhibitors, are reported. Simple substituent variation on aroyl moiety changes anti-AChE activity for two orders of magnitude; also substitution and type of hetero(ali)cycle in position 2 of
Jiahua Jiang et al.
PloS one, 7(3), e34283-e34283 (2012-04-06)
We have recently synthesized novel N-alkylated amino acid-derived hydroxamate, 2-[Benzyl-(2-nitro-benzenesulfonyl)-amino]-N-hydroxy-3-methyl-N-propyl-butyramide (NAHA). Here, we evaluate the anticancer activity of NAHA against highly invasive human breast cancer cells MDA-MB-231 in vitro and in vivo. Cell growth was evaluated by MTT and soft
L J Hellebrekers et al.
Laboratory animals, 24(3), 200-204 (1990-07-01)
A number of experiments was carried out to determine the sequence of events leading to death following administration of the euthanizing agent T61. Simultaneous recordings of the EMG, EEG, ECG and end-tidal CO2 (dogs only) were obtained in acutely instrumented
B P O'Hara et al.
Protein engineering, 13(2), 129-132 (2000-03-10)
The AmiC protein in Pseudomonas aeruginosa is the negative regulator and ligand receptor for an amide-inducible aliphatic amidase operon. In the wild-type PAC1 strain, amidase expression is induced by acetamide or lactamide, but not by butyramide. A mutant strain of
P Rocchi et al.
Anticancer research, 18(2A), 1099-1103 (1998-06-06)
Butyric acid has been shown in vitro to produce cytodifferentiation of a wide variety of neoplastic cells. The potential clinical use of this compound as a therapeutic agent is limited by its rapid metabolism. This has led to the examination

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