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196614

Sigma-Aldrich

2,6-Difluoroaniline

≥97%

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Synonym(s):
2,6-Difluorobenzenamine, 2,6-Difluorobenzeneamine, 2,6-Difluorophenylamine
Linear Formula:
F2C6H3NH2
CAS Number:
Molecular Weight:
129.11
Beilstein/REAXYS Number:
2802697
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

≥97%

form

liquid

refractive index

n20/D 1.508 (lit.)

bp

51-52 °C/15 mmHg (lit.)

density

1.199 g/mL at 25 °C (lit.)

SMILES string

Nc1c(F)cccc1F

InChI

1S/C6H5F2N/c7-4-2-1-3-5(8)6(4)9/h1-3H,9H2

InChI key

ODUZJBKKYBQIBX-UHFFFAOYSA-N

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1 of 4

This Item
D101400196835265306
2,6-Difluoroaniline ≥97%

196614

2,6-Difluoroaniline

2,4-Difluoroaniline 99%

D101400

2,4-Difluoroaniline

2,4,6-Trifluoroaniline ≥97%

196835

2,4,6-Trifluoroaniline

2,3-Difluoroaniline 98%

265306

2,3-Difluoroaniline

refractive index

n20/D 1.508 (lit.)

refractive index

n20/D 1.506 (lit.)

refractive index

-

refractive index

n20/D 1.514 (lit.)

form

liquid

form

liquid

form

solid

form

liquid

density

1.199 g/mL at 25 °C (lit.)

density

1.268 g/mL at 25 °C (lit.)

density

-

density

1.274 g/mL at 25 °C (lit.)

bp

51-52 °C/15 mmHg (lit.)

bp

170 °C/753 mmHg (lit.)

bp

57 °C/22 mmHg (lit.)

bp

-

Application

2,6-Difluoroaniline was used in the synthesis of:
  • N-2,6-difluorophenyl-5-methoxy-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide, herbicidal compound
  • series of 2,6,9-trisubstituted purine inhibitors of p38α kinase
  • substituted phenylthiomorpholine dioxide, an active pharmaceutical intermediate

pictograms

FlameExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Flam. Liq. 3 - Skin Sens. 1

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

123.8 °F - closed cup

flash_point_c

51 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Chao-Nan Chen et al.
Bioorganic & medicinal chemistry, 17(8), 3011-3017 (2009-04-04)
Triazolopyrimidine-2-sulfonamide belongs to a herbicide group called acetohydroxyacid synthase inhibitors. With the aim to discover new triazolopyrimidine sulfonanilide compounds with high herbicidal activity and faster degradation rate in soil, the methyl group of Flumetsulam (FS) was modified into a methoxy
Zehong Wan et al.
Bioorganic & medicinal chemistry letters, 13(6), 1191-1194 (2003-03-20)
The design, synthesis and SAR of a series of 2,6,9-trisubstituted purine inhibitors of p38alpha kinase is reported. Synthetic routes were devised to allow for array synthesis in which all three points of diversity could be facilely explored. The binding of
Catalyzed double Michael addition of anilines to vinyl sulfone.
Chen JJ, et al.
Tetrahedron Letters, 44(17), 3459-3462 (2003)
Irudayaraj Bernadette Amali et al.
Applied biochemistry and biotechnology, 190(2), 373-390 (2019-08-01)
In this article, we have reported the preparation and structural characterization of a new Schiff base ligand (E)-2-(((2,6-difluorophenyl)imino)methyl)phenol (HSBL) and its derived metal(II) complexes [Cu(SBL)2] (1), [Ni(SBL)2] (2) and [Pd(SBL)2] (3). Using various analytical and spectroscopic techniques, their structural properties
Simone K Schmidt et al.
Chirality, 29(1), 48-56 (2016-12-27)
For the enantiopure synthesis of novel chiral GABA uptake inhibitors, nipecotic acid (1) is an important key precursor. To characterize accurately the pharmacological activity of these interesting target compounds, the determination of the correct enantiomeric purity of nipecotic acid as

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